Self-testing for the detection of SARS-CoV-2 infection with rapid antigen tests for people.

  • Self-testing for COVID-19 infection with lateral movement assay SARS-CoV-2 rapid antigen detection tests (RDT), offers rapid outcomes and will allow frequent and intensive testing in the neighborhood, thereby bettering the management of SARS-CoV-2. The goal of this examine was to judge the efficiency of nasal mid-turbinate self-testing utilizing RDT for individuals suspected with COVID-19 in the neighborhood.
  • Participants visiting a municipal SARS-CoV-2 testing centre, obtained self-testing kits containing both the BD Veritor System (BD-RDT) or Roche SARS-CoV-2 antigen detection take a look at (Roche-RDT). Oro-nasopharyngeal swabs had been collected from the individuals for qRT-PCR testing. As a proxy for contagiousness, viral tradition was carried out on a range of qRT-PCR constructive samples to find out the Ct-value at which the probability of a constructive tradition was dropping under 0.5 (Ct-value cut-off). Sensitivity and specificity of self-testing had been in comparison with qRT-PCR with a Ct-value under the Ct worth cut-off. Determinants independently related with a false-negative self-test end result had been decided.
  • A complete of 3,201 individuals had been included (BD-RDT n=1595; Roche-RDT n=1606). Sensitivity and specificity of self-testing in comparison with the qRT-PCR outcomes with a Ct-value under the Ct-value cut-off was 78.4% (95% CI:73.2-83.5) and 99.4% (95%CI: 99.1-99.7) respectively. The next age was independently related with a false-negative self-testing end result with an odds ratio of 1.024 (95%CI:1.003-1.044).
  • Self-testing utilizing at present out there RDT’s has a excessive specificity and Roche rapid antigen test sensitivity comparatively excessive sensitivity to establish people with a excessive likelihood of contagiousness.

A Rapid, High-Sensitivity SARS-CoV-2 Nucleocapsid Immunoassay to Aid Diagnosis of Acute COVID-19 at the Point of Care: A Clinical Performance Study

  1. The LumiraDx extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen take a look at, which makes use of a high-sensitivity, microfluidic immunoassay to detect the nucleocapsid protein of SARS-CoV-2, was evaluated for diagnosing acute coronavirus illness 2019 (COVID-19) in adults and kids throughout point-of-care settings (NCT04557046).
  2. Two paired anterior nasal swabs or two paired nasopharyngeal swabs had been collected from every participant. Swabs had been take a look ated by the LumiraDx SARS-CoV-2 antigentake a look at and in contrast with real-time polymerase chain response (rt-PCR; Roche cobas 6800 platform). Sensitivity, specificity and probability ratios had been calculated. Results had been stratified on the foundation of gender, age, period of signs, and rt-PCR cycle threshold.
  3. Out of the 512 individuals, aged 0-90 years, of this potential validation examine, 414 (81%) had been symptomatic for COVID-19 and 123 (24%) swabs had been constructive for SARS-CoV-2 primarily based on rt-PCR take a look ating. Compared with rt-PCR, the 12-min nasal swab take a look at had 97.6% sensitivity and 96.6% specificity, and nasopharyngeal swab had 97.5% sensitivity and 97.7% specificity, inside 12 days of symptom onset, representing the interval of infectivity. All (100%) samples detected inside 33 rt-PCR cycles had been additionally recognized utilizing the antigen take a look at. Results had been constant throughout age and gender. The person error price of the take a look at system when utilized by minimally educated operators was 0.7% (95% confidence interval [CI] 0.1-3.7%).
Antigen Rapid Test
Antigen Rapid Test

The rapid, high-sensitivity assay utilizing nasopharyngeal or anterior nasal sampling might supply important enhancements for diagnosing acute SARS-CoV-2 infection in clinic- and community-based settings. COVID-19; LumiraDx antigen take a look at; Rt-PCR; SARS-Co.

Detection of SARS-CoV-2 infection in the basic inhabitants by three prevailing rapid antigen tests
Rapid antigen diagnostic tests (Ag-RDTs) are the most generally used point-of-care tests for detecting SARS-CoV-2 infection. Since the accuracy might have altered by adjustments in SARS-CoV-2 epidemiology, indications for testing, sampling and testing procedures, and roll-out of COVID-19 vaccination, we evaluated the efficiency of three prevailing SARS-CoV-2 Ag-RDTs.
  • In this cross-sectional examine, we consecutively enrolled people aged >16 years presenting for SARS-CoV-2 testing at three Dutch public well being service COVID-19 take a look at websites. In the first part, individuals underwent both BD-Veritor System (Becton Dickinson), PanBio (Abbott), or SD-Biosensor (Roche Diagnostics) testing with routine sampling procedures. In a subsequent part, individuals underwent SD-Biosensor testing with a much less invasive sampling technique (mixed oropharyngeal-nasal [OP-N] swab). Diagnostic accuracies had been assessed in opposition to molecular testing.
  • Six thousand 9 hundred fifty-five of 7005 individuals (99%) with outcomes from each an Ag-RDT and a molecular reference take a look at had been analysed. SARS-CoV-2 prevalence and general sensitivities had been 13% (188/1441) and 69% (129/188, 95% CI 62-75) for BD-Veritor, 8% (173/2056) and 69% (119/173, 61-76) for PanBio, and 12% (215/1769) and 74% (160/215, 68-80) for SD-Biosensor with routine sampling and 10% (164/1689) and 75% (123/164, 68-81) for SD-Biosensor with OP-N sampling. In these symptomatic or asymptomatic at sampling, sensitivities had been 72-83% and 54-56%, respectively.
  • Above a viral load cut-off (≥5.2 log10 SARS-CoV-2 E-gene copies/mL), sensitivities had been 86% (125/146, 79-91) for BD-Veritor, 89% (108/121, 82-94) for PanBio, and 88% (160/182, 82-92) for SD-Biosensor with routine sampling and 84% (118/141, 77-89) with OP-N sampling. Specificities had been >99% for all tests in most analyses. Sixty-one per cent of false-negative Ag-RDT individuals returned for testing inside 14 days (median: Three days, interquartile vary 3) of whom 90% examined constructive.
  • Overall sensitivities of three SARS-CoV-2 Ag-RDTs had been 69-75%, growing to ≥86% above a viral load cut-off. The decreased sensitivity amongst asymptomatic individuals and excessive positivity price throughout follow-up in false-negative Ag-RDT individuals emphasise the want for schooling of the public about the significance of re-testing after an preliminary damaging Ag-RDT ought to signs develop. For SD-Biosensor, the diagnostic accuracy with OP-N and deep nasopharyngeal sampling was related; adopting the extra handy sampling technique would possibly cut back the threshold for skilled testing.

Performance of the LumiraDx Microfluidic Immunofluorescence Point-of-Care SARS-CoV-2 Antigen Test in Asymptomatic Adults and Children

The LumiraDx SARS-CoV-2 Ag Test has beforehand been proven to precisely detect extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in people symptomatic for coronavirus illness 2019 (COVID-19). This analysis investigated the LumiraDx SARS-CoV-2 Ag Test as an support in the analysis of SARS-CoV-2 infection in asymptomatic adults and kids.
  1. Asymptomatic people at excessive danger of COVID-19 infection had been recruited in 5 point-of-care (POC) settings. Two paired anterior nasal swabs had been collected from every participant, examined through the use of the LumiraDx SARS-CoV-2 Ag Test at the POC, and in contrast with outcomes from reverse transcription-polymerase chain response (RT-PCR) assays (cobas 6800 [Roche Diagnostics] or TaqPath [Thermo Fisher Scientific]). We calculated constructive % settlement (PPA) and damaging % settlement (NPA), then stratified outcomes on the foundation of RT-PCR reference platform and cycle threshold.
  2. Of the 222 included examine individuals confirmed to be symptom-free for a minimum of 2 weeks earlier than testing, the PPA was 82.1% (95% confidence interval [CI], 64.4%-92.1%). The LumiraDx SARS-CoV-2 Ag Test appropriately recognized 95.8% (95% CI, 79.8%-99.3%) of the samples confirmed constructive in fewer than 33 RT-PCR cycles and 100% (95% CI, 85.1%-100%) in fewer than 30 RT-PCR cycles whereas sustaining 100% NPA.

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IHP-N602 Hangzhou AllTest Biotech 1 kit

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Rabies Virus Antigen Test Card

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Feline Giardia Antigen Test Card

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Canine Relaxin Antigen Test Card

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Canine Rotavirus Antigen Test Card

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Canine Heartworm Antigen Test Card

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Feline Heartworm Antigen Test Card

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Canine Pancreatitis Antigen Test Card

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S. pneumoniae Antigen Rapid Test

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Norovirus Antigen Rapid Test Kit

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Toxoplasma Antigen Rapid Test Card

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Adenovirus Antigen and Rotavirus Antigen Rapid Test Kit

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Canine Parvovirus (CPV) Antigen Test Card

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Salmonella typhi Antigen Rapid Test

ISTY-N602 Hangzhou AllTest Biotech 1 kit

NOVATest Antigen Rapid Test Kit (For Single Use) (NOVA Test)

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Canine Coronavirus (CCV) Antigen Test Card

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Feline Calicivirus (FCV) Antigen Test Card

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Feline Calicivirus (FCV) Antigen Test Card

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Feline Coronavirus (FCoV) Antigen Test Card

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Canine coronavirus (CCoV) Antigen Test Card

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Feline coronavirus (FCoV) Antigen Test Card

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Borrelia Afzelii Antigen

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Borrelia Afzelii Antigen

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Borrelia Garinii Antigen

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Borrelia Garinii Antigen

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Brucella Abortus Antigen

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Brucella Abortus Antigen

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Candida Albicans Antigen

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Candida Albicans Antigen

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CDV/CAV Antigen Combo Test Card

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Canine Parvovirus Antigen

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Canine Coronavirus Antigen

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Feline Calicivirus Antigen

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CPV&CCoV Antigen Rapid Test Card

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CDV/CPIV Antigen Combo Test Card

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Canine Parainfluenza Virus Antigen Test Card

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Helicobacter Pylori Antigen

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Helicobacter Pylori Antigen

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Campylobacter Jejuni Antigen

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Campylobacter Jejuni Antigen

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SARS-CoV-2 Antigen Rapid Test

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Chlamydia Trachomatis Antigen

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Mycoplasma Pneumoniae Antigen

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Mycoplasma Pneumoniae Antigen

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Echovirus Antigen, Recombinant

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Echovirus Antigen, Recombinant

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Neisseria Gonorrhoeae Antigen

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Trichomonas Vaginalis Antigen

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Recombinant human RHD antigen 

P1958 FN Test 100ug

Dog rabies Antigen rapid test card

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Enterovirus Antigen, Recombinant

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Enterovirus Antigen, Recombinant

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Echinococcus Granulosus Antigen

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Rabies Virus Antigen Rapid Test Kit

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Rabies Virus Antigen Rapid Test Kit

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Rabies Virus Antigen Rapid Test Kit

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Cytomegalovirus Purified Antigen

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Cytomegalovirus Purified Antigen

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Astrovirus Antigen (Type 1)

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Astrovirus Antigen (Type 1)

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Yersinia pestis V antigen

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Yersinia pestis V antigen

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Canine Herpes Virus Antigen

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Feline Herpes Virus (FHV) Antigen Test Card

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Feline Herpes Virus (FHV) Antigen Test Card

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NOVATest Antigen Rapid Kit (NOVA Test)

nCov-500 Atlas Link Technology 20 Tests

Canine Adenovirus 1 Antigen

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Canine Adenovirus 2 Antigen

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Canine Adenovirus 2 (CAV) Antigen Test Card

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Canine Distemper Virus Antigen

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Canine Adenovirus Type I Antigen Test Card

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Human Rotavirus Antigen Rapid Test Kit

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Human Rotavirus Antigen Rapid Test Kit

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Human Rotavirus Antigen Rapid Test Kit

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Feline Leukemia Virus(FeLV) Antigen Test Card

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Canine Distemper Virus (CDV) Antigen Test Card

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Canine Influenza Virus (CIV) Antigen Test Card

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Feline Leukosis Virus (FeLV) Antigen Test Card

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Canine Early Pregnancy (RLN) Antigen Test Card

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Norovirus GII.4 VP1 Antigen

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Norovirus GII.4 VP1 Antigen

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Norovirus GII.4 VP1 Antigen

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Canine Parainfluenza Virus Antigen

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Feline Panleukopenia Virus Antigen

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Rat CA125(Carbohydrate Antigen 125) ELISA Kit

ER0788 FN Test 96T

Rat Cd44(CD44 antigen) ELISA Kit

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Dog Toxoplasmosis Antigen Rapid Test Kit

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Dog Toxoplasmosis Antigen Rapid Test Kit

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Dog Toxoplasmosis Antigen Rapid Test Kit

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Canine Parvovirus Antigen Rapid Test Kit

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Canine Parvovirus Antigen Rapid Test Kit

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Canine Parvovirus Antigen Rapid Test Kit

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Canine Adenovirus Antigen Rapid Test Kit

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Canine Adenovirus Antigen Rapid Test Kit

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Canine Adenovirus Antigen Rapid Test Kit

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Cytomegalovirus Cell Lysate Antigen

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Mouse CA125(Carbohydrate Antigen 125) ELISA Kit

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Feline Viral Rhinotracheitis Antigen

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CDV/CAV/CIV Antigen Combo Test Card

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Bird Flu H9 antigen rapid test card

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Bird Flu H5 antigen rapid test card

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Canine Coronavirus Antigen Rapid Test Kit

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Canine Coronavirus Antigen Rapid Test Kit

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Feline Coronavirus Antigen Rapid Test Kit

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Feline Coronavirus Antigen Rapid Test Kit

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Feline Coronavirus Antigen Rapid Test Kit

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Dengue Antigen for Rapid Test Recombinant

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Herpes Simplex Virus 1 Antigen

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Herpes Simplex Virus 1 Antigen

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Herpes Simplex Virus 2 Antigen

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Herpes Simplex Virus 2 Antigen

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Mouse CD44( CD44 antigen) ELISA Kit

EM0433 FN Test 96T

Rat Alcam(CD166 antigen) ELISA Kit

ER0216 FN Test 96T

Human CD44(CD44 antigen) ELISA Kit

EH0654 FN Test 96T

Human CD48(CD48 antigen) ELISA Kit

EH4332 FN Test 96T

Human CD81(CD81 antigen) ELISA Kit

EH7221 FN Test 96T

CPV&CCoV&GIA Antigen Rapid Test Card

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Feline Panleukopenia Virus (FPV) Antigen Test Card

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Recombinant human Lymphocyte antigen 6K

P2272 FN Test 100ug

Mouse Alcam(CD166 antigen) ELISA Kit

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Human ALCAM(CD166 antigen) ELISA Kit

EH0001 FN Test 96T

Human CD276(CD276 antigen) ELISA Kit

EH0634 FN Test 96T

Human CD109(CD109 antigen) ELISA Kit

EH1701 FN Test 96T

Human CD177(CD177 antigen) ELISA Kit

EH1752 FN Test 96T

SARS-CoV-2 Antigen Rapid Test Kit

CoV2Ag-1 UnScience 1T

SARS-CoV-2 Antigen Rapid Test Kit

CoV2Ag-25 UnScience 25T/kit

SARS-CoV-2 Antigen Rapid Test Kit

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SARS-CoV-2 Antigen Rapid Test Kit

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SARS-CoV-2 Antigen Rapid Test Kit

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SARS-CoV-2 Antigen Rapid Test Kit

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Ross River Virus Recombinant Antigen

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Ross River Virus Recombinant Antigen

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Human CA-125(Carbohydrate Antigen 125) ELISA Kit

EH0361 FN Test 96T

Dengue Virus NS1 Antigen Rapid Test Kit

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Dengue Virus NS1 Antigen Rapid Test Kit

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Dengue Virus NS1 Antigen Rapid Test Kit

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Typhoid Antigen (S. typhi) Rapid Test Kit

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Typhoid Antigen (S. typhi) Rapid Test Kit

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Typhoid Antigen (S. typhi) Rapid Test Kit

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Human MKI67(Antigen KI-67) ELISA Kit

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Hepatitis B Virus E Antigen (HBeAg)

REC31677-100 The Native Antigen Company 0.1

Hepatitis B Virus E Antigen (HBeAg)

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Canine Adenovirus 1 and 2 Antigen

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COVID-19 Antigen Rapid Test Pen (Saliva)

BSV-COV-2PEN20 BioServUK 20 pc

Mouse CD5l( CD5 antigen-like) ELISA Kit

EM0762 FN Test 96T

Human CD5L(CD5 antigen-like) ELISA Kit

EH2229 FN Test 96T

Hepatitis B Virus Core Antigen (HBcAg)

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Hepatitis B Virus Core Antigen (HBcAg)

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Hepatitis C Virus Core Antigen (HCcAg)

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Human CD52(CAMPATH-1 antigen) ELISA Kit

EH1286 FN Test 96T

Human CEA(Carcinoembryonic Antigen) ELISA Kit

EH0090 FN Test 96T

Herpes Simplex Virus 1 Lysate Antigen

HS104-1000 The Native Antigen Company 1.0

Herpes Simplex Virus 2 Lysate Antigen

HS204-1000 The Native Antigen Company 1.0

Feline Infectious Peritonitis Virus Antigen

NAT41596-100 The Native Antigen Company 0.1

Healgen Coronavirus Rapid Antigen Test (Professional use)

BSV-GCCOV-502a-20 BioServUK 20 tests

Recombinant human B-lymphocyte antigen CD19

P1837 FN Test 100ug

Recombinant human B-lymphocyte antigen CD20

P2398 FN Test 100ug

Human LY75(Lymphocyte antigen 75) ELISA Kit

EH0299 FN Test 96T

Dog Giardia lamblia Antigen Rapid Test Kit

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Dog Giardia lamblia Antigen Rapid Test Kit

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Dog Giardia lamblia Antigen Rapid Test Kit

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African Swine Fever Antigen Rapid Test Kit

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African Swine Fever Antigen Rapid Test Kit

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African Swine Fever Antigen Rapid Test Kit

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Helicobacter pylori Antigen Fluorescence Test Kit

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Legionella pneumophila antigen (native extract)

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Rat PSA(Prostate Specific Antigen) ELISA Kit

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Recombinant human Antigen peptide transporter 1

P1680 FN Test 100ug

Mouse Ly6c1( Lymphocyte antigen 6C1) ELISA Kit

EM0555 FN Test 96T

Rat TPA(Tissue Polypeptide Antigen) ELISA Kit

ER1398 FN Test 96T

Human CA50(Carbohydrate Antigen 50) ELISA Kit

EH1396 FN Test 96T

Streptococcus Pneumoniae Antigen, Native Extract

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Leptospira Biflexa Antigen (Strain Patoc 1)

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Mouse PSA(Prostate Specific Antigen) ELISA Kit

EM1314 FN Test 96T

Rapid Response COVID-19 Saliva Rapid Antigen Test

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Prostate Specific Antigen (PSA) Rapid Test Kit

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Prostate Specific Antigen (PSA) Rapid Test Kit

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Prostate Specific Antigen (PSA) Rapid Test Kit

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Avian Influenza Virus Antigen Rapid Test Kit

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Feline Leukemia Virus Antigen Rapid Test Kit

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Swine Influenza Virus Antigen Rapid Test Kit

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Human Giardia lamblia Antigen Rapid Test Kit

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Human Giardia lamblia Antigen Rapid Test Kit

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Human Giardia lamblia Antigen Rapid Test Kit

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Recombinant human Melanoma-associated antigen 3

P1547 FN Test 100ug

Recombinant human Melanoma-associated antigen 2

P1622 FN Test 100ug

Mouse TPA(Tissue Polypeptide Antigen) ELISA Kit

EM1633 FN Test 96T

Human TPA(Tissue Polypeptide Antigen) ELISA Kit

EH3901 FN Test 96T

Human HLA-A(Leukocyte Antigen A) ELISA Kit

EH3227 FN Test 96T

Feline Herpesvirus (FHV) Antigen Rapid Test Kit

abx092275-100l Abbexa 100 µl

Feline Herpesvirus (FHV) Antigen Rapid Test Kit

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Feline Herpesvirus (FHV) Antigen Rapid Test Kit

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Feline Calicivirus (FCV) Antigen Rapid Test Kit

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Feline Calicivirus (FCV) Antigen Rapid Test Kit

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Feline Calicivirus (FCV) Antigen Rapid Test Kit

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Canine Distemper Virus Antigen Rapid Test Kit

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Canine Distemper Virus Antigen Rapid Test Kit

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Canine Distemper Virus Antigen Rapid Test Kit

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Canine Influenza Virus Antigen Rapid Test Kit

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Canine Influenza Virus Antigen Rapid Test Kit

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Canine Influenza Virus Antigen Rapid Test Kit

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Human Candida albicans Antigen Rapid Test Kit

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Human Candida albicans Antigen Rapid Test Kit

abx472009-596tests Abbexa 5 × 96 tests

Human Candida albicans Antigen Rapid Test Kit

abx472009-96tests Abbexa 96 tests

Canine Parvovirus(CPV) antigen rapid test card

LSY-20036 Shenzhen Lvshiyuan Biotechnology 10 test/kit

Malaria PF and PV Antigen Rapid Test Kit

abx092211-100l Abbexa 100 µl

Malaria PF and PV Antigen Rapid Test Kit

abx092211-1ml Abbexa 1 ml

Malaria PF and PV Antigen Rapid Test Kit

abx092211-200l Abbexa 200 µl

Rat Tp53(Cellular tumor antigen p53) ELISA Kit

ER0394 FN Test 96T

Human GPA33(Cell surface A33 antigen) ELISA Kit

EH1535 FN Test 96T

Newcastle Disease Virus Antigen Rapid Test Kit

abx092016-100l Abbexa 100 µl
This rapid, high-sensitivity take a look at can be utilized to display asymptomatic sufferers for acute SARS-CoV-2 infection in clinic- and community-based settings.Asymptomatic; COVID-19; LumiraDx antigen take a look at; RT-PCR; SARS-CoV-2; Sensitivity.

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