Effect of anti-TP0136 antibodies on the progression of lesions in an infected rabbit model.

TP0136 anti-syphilis antibodies in development are poorly understood. This study aimed to determine the effect of anti-TP0136 antibodies on lesion development in infected rabbit models. rTP0136 intramuscular injection into rabbits in the immunized group (n = 4) induce high titers of anti TP0136-antibody, and rabbit then challenged with 105T. pallidum per site along their back. lesion development was observed, and the injection sites were biopsied for tp0574 mRNA and histological analysis every week until the wound is healed. Rabbits in the control group were injected with normal saline instead rTP0136. Decent T. pallidum in rabbits challenged assessed by a test rabbit infectivity.

Lesions in the immunized group took longer to heal than in the control group (42 d vs 28 d, P <0.001) and had a real level higher than the number of cellular infiltrates. MRNA levels of tp0574 the immunized group was significantly higher than in the control group (P <0.05). Decent T. pallidum detected in the lymph nodes of rabbits in both groups were immunized and control. Our study shows that a high titer antibody anti TP0136-promoted infiltration of inflammatory cells into the local lesions and tissue damage intensive, thereby delaying wound healing, and does not have a protective effect on the occurrence of syphilis in a rabbit model.

Kinesis See Part Number P-332 - PK10
CHR4033 PK10
EUR 22.38

piggyBac qPCR copy number kit, 20 reactions  
PBC100A-1 20 reactions
EUR 275

copy number positive control for custom assay
Z-any-std each
EUR 198

Drain Tap Assembly to suit baths with serial number: 75100 - EACH
BAT7360 EACH
EUR 89.1

Lci5 | low carbon dioxide induced protein number 5
AS05-090 100 µl
EUR 394

copy number positive control for custom rat assay
Z-ra-std each
EUR 198
Description: Control

SOD1 aa 80-96 | superoxide dismutase 1, soluble (clone number 210,29)
AS13-2645 50 µg
EUR 369

Recombinant Zea mays Cell number regulator 4 (CNR4)
MBS1167225-INQUIRE INQUIRE Ask for price

Recombinant Zea mays Cell number regulator 5 (CNR5)
MBS1194222-INQUIRE INQUIRE Ask for price

Recombinant Zea mays Cell number regulator 9 (CNR9)
MBS1176992-INQUIRE INQUIRE Ask for price

Recombinant Zea mays Cell number regulator 7 (CNR7)
MBS1162771-INQUIRE INQUIRE Ask for price

Recombinant Zea mays Cell number regulator 1 (CNR1)
MBS1113783-INQUIRE INQUIRE Ask for price

Recombinant Zea mays Cell number regulator 8 (CNR8)
MBS1002198-INQUIRE INQUIRE Ask for price

Recombinant Zea mays Cell number regulator 6 (CNR6)
MBS1065010-INQUIRE INQUIRE Ask for price

Recombinant Zea mays Cell number regulator 2 (CNR2)
MBS1061318-INQUIRE INQUIRE Ask for price

Recombinant Zea mays Cell number regulator 3 (CNR3)
MBS1127062-INQUIRE INQUIRE Ask for price

Recombinant Zea mays Cell number regulator 1 (CNR1)
MBS7011906-002mg 0.02mg
EUR 1475

Recombinant Zea mays Cell number regulator 1 (CNR1)
MBS7011906-01mg 0.1mg
EUR 2435

Recombinant Zea mays Cell number regulator 1 (CNR1)
MBS7011906-5x01mg 5x0.1mg
EUR 10920

Recombinant Zea mays Cell number regulator 2 (CNR2)
MBS7011915-002mg 0.02mg
EUR 1460

Recombinant Zea mays Cell number regulator 2 (CNR2)
MBS7011915-01mg 0.1mg
EUR 2425

Recombinant Zea mays Cell number regulator 2 (CNR2)
MBS7011915-5x01mg 5x0.1mg
EUR 10870

Recombinant Zea mays Cell number regulator 3 (CNR3)
MBS7011916-002mg 0.02mg
EUR 1445

Recombinant Zea mays Cell number regulator 3 (CNR3)
MBS7011916-01mg 0.1mg
EUR 2410

Recombinant Zea mays Cell number regulator 3 (CNR3)
MBS7011916-5x01mg 5x0.1mg
EUR 10795

Recombinant Zea mays Cell number regulator 4 (CNR4)
MBS7011917-002mg 0.02mg
EUR 1435

Recombinant Zea mays Cell number regulator 4 (CNR4)
MBS7011917-01mg 0.1mg
EUR 2400

Recombinant Zea mays Cell number regulator 4 (CNR4)
MBS7011917-5x01mg 5x0.1mg
EUR 10755

Recombinant Zea mays Cell number regulator 5 (CNR5)
MBS7011918-002mg 0.02mg
EUR 1465

Recombinant Zea mays Cell number regulator 5 (CNR5)
MBS7011918-01mg 0.1mg
EUR 2430

Recombinant Zea mays Cell number regulator 5 (CNR5)
MBS7011918-5x01mg 5x0.1mg
EUR 10880

Recombinant Zea mays Cell number regulator 6 (CNR6)
MBS7011919-002mg 0.02mg
EUR 1530

Recombinant Zea mays Cell number regulator 6 (CNR6)
MBS7011919-01mg 0.1mg
EUR 2495

Recombinant Zea mays Cell number regulator 6 (CNR6)
MBS7011919-5x01mg 5x0.1mg
EUR 11175

Recombinant Zea mays Cell number regulator 7 (CNR7)
MBS7011920-002mg 0.02mg
EUR 1460

Recombinant Zea mays Cell number regulator 7 (CNR7)
MBS7011920-01mg 0.1mg
EUR 2425

Recombinant Zea mays Cell number regulator 7 (CNR7)
MBS7011920-5x01mg 5x0.1mg
EUR 10860

Recombinant Zea mays Cell number regulator 8 (CNR8)
MBS7011921-002mg 0.02mg
EUR 1525

Recombinant Zea mays Cell number regulator 8 (CNR8)
MBS7011921-01mg 0.1mg
EUR 2485

Recombinant Zea mays Cell number regulator 8 (CNR8)
MBS7011921-5x01mg 5x0.1mg
EUR 11145

Recombinant Zea mays Cell number regulator 9 (CNR9)
MBS7011922-002mg 0.02mg
EUR 1455

Recombinant Zea mays Cell number regulator 9 (CNR9)
MBS7011922-01mg 0.1mg
EUR 2420

Recombinant Zea mays Cell number regulator 9 (CNR9)
MBS7011922-5x01mg 5x0.1mg
EUR 10835

Recombinant Zea mays Cell number regulator 13 (CNR13)
MBS1148076-INQUIRE INQUIRE Ask for price

Recombinant Zea mays Cell number regulator 10 (CNR10)
MBS1163170-INQUIRE INQUIRE Ask for price

Recombinant Zea mays Cell number regulator 11 (CNR11)
MBS1009377-INQUIRE INQUIRE Ask for price

Recombinant Zea mays Cell number regulator 10 (CNR10)
MBS7011907-002mg 0.02mg
EUR 1435

Recombinant Zea mays Cell number regulator 10 (CNR10)
MBS7011907-01mg 0.1mg
EUR 2395

Recombinant Zea mays Cell number regulator 10 (CNR10)
MBS7011907-5x01mg 5x0.1mg
EUR 10740

Recombinant Zea mays Cell number regulator 11 (CNR11)
MBS7011908-002mg 0.02mg
EUR 1435

Recombinant Zea mays Cell number regulator 11 (CNR11)
MBS7011908-01mg 0.1mg
EUR 2400

Recombinant Zea mays Cell number regulator 11 (CNR11)
MBS7011908-5x01mg 5x0.1mg
EUR 10750

Recombinant Zea mays Cell number regulator 13 (CNR13)
MBS7011909-002mg 0.02mg
EUR 1760

Recombinant Zea mays Cell number regulator 13 (CNR13)
MBS7011909-01mg 0.1mg
EUR 2715

Recombinant Zea mays Cell number regulator 13 (CNR13)
MBS7011909-5x01mg 5x0.1mg
EUR 12180

copy number positive control for custom human assay
Z-hu-std each
EUR 217
Description: Control

copy number positive control for custom mouse assay
Z-mo-std each
EUR 198

Recombinant Clostridium perfringens Copy number protein (cop)
MBS1040490-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1120

Recombinant Clostridium perfringens Copy number protein (cop)
MBS1040490-002mgEColi 0.02mg(E-Coli)
EUR 700

Recombinant Clostridium perfringens Copy number protein (cop)
MBS1040490-002mgYeast 0.02mg(Yeast)
EUR 870

Recombinant Clostridium perfringens Copy number protein (cop)
MBS1040490-01mgEColi 0.1mg(E-Coli)
EUR 835

Recombinant Clostridium perfringens Copy number protein (cop)
MBS1040490-01mgYeast 0.1mg(Yeast)
EUR 1020

Recombinant Zea mays Cell number regulator 5 (CNR5), partial
MBS7066450-INQUIRE INQUIRE Ask for price

Recombinant Zea mays Cell number regulator 8 (CNR8), partial
MBS7066974-INQUIRE INQUIRE Ask for price

Recombinant Zea mays Cell number regulator 6 (CNR6), partial
MBS7067144-INQUIRE INQUIRE Ask for price

Recombinant Zea mays Cell number regulator 1 (CNR1), partial
MBS7067283-INQUIRE INQUIRE Ask for price

Recombinant Zea mays Cell number regulator 2 (CNR2), partial
MBS7067894-INQUIRE INQUIRE Ask for price

Recombinant Zea mays Cell number regulator 3 (CNR3), partial
MBS7069497-INQUIRE INQUIRE Ask for price

Recombinant Zea mays Cell number regulator 9 (CNR9), partial
MBS7069888-INQUIRE INQUIRE Ask for price

Recombinant Zea mays Cell number regulator 4 (CNR4), partial
MBS7070088-005mgMammalianCell 0.05mg(Mammalian-Cell)
EUR 690

Recombinant Zea mays Cell number regulator 4 (CNR4), partial
MBS7070088-02mgMammalianCell 0.2mg(Mammalian-Cell)
EUR 895

Recombinant Zea mays Cell number regulator 4 (CNR4), partial
MBS7070088-05mgMammalianCell 0.5mg(Mammalian-Cell)
EUR 980

Recombinant Zea mays Cell number regulator 4 (CNR4), partial
MBS7070088-1mgMammalianCell 1mg(Mammalian-Cell)
EUR 1340

Recombinant Zea mays Cell number regulator 7 (CNR7), partial
MBS7070257-INQUIRE INQUIRE Ask for price

Recombinant Zea mays Cell number regulator 13 (CNR13), partial
MBS7067390-INQUIRE INQUIRE Ask for price

Recombinant Zea mays Cell number regulator 11 (CNR11), partial
MBS7069709-INQUIRE INQUIRE Ask for price

Recombinant Zea mays Cell number regulator 10 (CNR10), partial
MBS7069858-INQUIRE INQUIRE Ask for price

Trametinib, DMSO Solvate [CAS# 1187431-43-1]
T-8188 10 mg
EUR 38

Kinesis Septa TCS 11mm Bought as part number without /S - EACH
CHR1750 EACH
EUR 4.8

SOD1 aa 58-72 | Superoxide dismutase 1, soluble (clone number 15,13)
AS13-2644 50 µg
EUR 369

Kinesis Obsolete see part number M-653 Headless; 10-32; 1/16
CHR3683 PK10
EUR 50.16

ASyM | Mouse anti-human alpha synuclein N-terminal (clone number 4,2)
AS13-2719 50 µg
EUR 618

SOD1 aa 24-39 | superoxide dismutase 1, soluble (clone number 6D4,G9,C3,2)
AS13-2643 50 µg
EUR 369

ASyO2 | Mouse anti-human alpha-synuclein | oligomer-specific (clone number 51,24)
AS13-2717 50 µg
EUR 618

ASyO5 | Mouse anti-human alpha-synuclein | oligomer-specific (clone number 2,4)
AS13-2718 50 µg
EUR 618

Mouse macrophage inflammatory protein 3beta, MIP-3beta (Cat number does not match description) ELISA Kit
MBS164244-10x96StripWells 10x96-Strip-Wells
EUR 3955

Mouse macrophage inflammatory protein 3beta, MIP-3beta (Cat number does not match description) ELISA Kit
MBS164244-48StripWells 48-Strip-Wells
EUR 305

Mouse macrophage inflammatory protein 3beta, MIP-3beta (Cat number does not match description) ELISA Kit
MBS164244-5x96StripWells 5x96-Strip-Wells
EUR 2005

Mouse macrophage inflammatory protein 3beta, MIP-3beta (Cat number does not match description) ELISA Kit
MBS164244-96StripWells 96-Strip-Wells
EUR 475

DMSO
40470004-1 500 mL
EUR 84.91

DMSO
40470004-2 1 L
EUR 131.98

DMSO
40470004-3 100 mL
EUR 41.74

DMSO
40470004-4 250 mL
EUR 50.52

DMSO
40470004-5 50 mL
EUR 27.89

DiTO™-1 [equivalent to TOTO®-1] *5 mM DMSO Solution* *CAS 143413-84-7*
17575 0.2 ml
EUR 227
Description: DiTO™-1 is chemically equivalent to TOTO®-1 (TOTO® is the trademark of Invitrogen).

DiTO™-1 [equivalent to TOTO®-1] *5 mM DMSO Solution* *CAS 143413-84-7*
17575-02ml 0.2 ml
EUR 222
Description: DiTO™-1 is chemically equivalent to TOTO®-1 (TOTO® is the trademark of Invitrogen).

DiYO™-3 [equivalent to YOYO®-3] *5 mM DMSO Solution* *CAS 156312-20-8*
17581 0.2 ml
EUR 227
Description: DiYO™-3 is chemically equivalent to YOYO®-3 (YOYO® is the trademark of Invitrogen).

DiYO™-3 [equivalent to YOYO®-3] *5 mM DMSO Solution* *CAS 156312-20-8*
17581-02ml 0.2 ml
EUR 222
Description: DiYO™-3 is chemically equivalent to YOYO®-3 (YOYO® is the trademark of Invitrogen).

DMSO, anhydrous
90082-1 EA
EUR 31

Dimethylsulfoxide (DMSO), 500ml
PC0906-500ml each Ask for price

Dry DMSO, 2ML
X022-2ML 2ML
EUR 37

Dry DMSO, 4ML
X022-4ML 4ML
EUR 54

Dry DMSO, 5ML
X022-5ML 5ML
EUR 59

Dry DMSO, 14ML
X022-14ML 14ML
EUR 109

Dry DMSO, 20ML
X022-20ML 20ML
EUR 168

TWO-PRO™ 1 [equivalent to TO-PRO®-1] *5 mM DMSO Solution* *CAS 157199-59-2*
17571 0.2 ml
EUR 227
Description: TWO-PRO™-1 is chemically equivalent to TO-PRO®-1 (TO-PRO® is the trademark of Invitrogen).

TWO-PRO™ 1 [equivalent to TO-PRO®-1] *5 mM DMSO Solution* *CAS 157199-59-2*
17571-02ml 0.2 ml
EUR 222
Description: TWO-PRO™-1 is chemically equivalent to TO-PRO®-1 (TO-PRO® is the trademark of Invitrogen).

TWO-PRO™ 3 [equivalent to TO-PRO®-3] *5 mM DMSO Solution* *CAS 157199-63-8*
17572 0.2 ml
EUR 227
Description: TWO-PRO™-3 is chemically equivalent to TO-PRO®-3 (TO-PRO® is the trademark of Invitrogen).

TWO-PRO™ 3 [equivalent to TO-PRO®-3] *5 mM DMSO Solution* *CAS 157199-63-8*
17572-02ml 0.2 ml
EUR 222
Description: TWO-PRO™-3 is chemically equivalent to TO-PRO®-3 (TO-PRO® is the trademark of Invitrogen).

Trametinib DMSO solvate
123211 10.0mg
EUR 90

Trametinib DMSO solvate
A3887-10 10 mg
EUR 40
Description: MAPK Signaling|MEK1/2

Trametinib DMSO solvate
A3887-100 100 mg
EUR 95.2
Description: MAPK Signaling|MEK1/2

Trametinib DMSO solvate
A3887-5.1 10 mM (in 1mL DMSO)
EUR 44
Description: MAPK Signaling|MEK1/2

Trametinib DMSO solvate
A3887-50 50 mg
EUR 64
Description: MAPK Signaling|MEK1/2

Dimethyl sulfoxide (DMSO)
D0231 500ml
EUR 88.55

Trametinib (DMSO solvate)
HY-10999A 100mg
EUR 75.76
Description: Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate);JTP-74057 (DMSO solvate)) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib (DMSO solvate) activates autophagy and induces apoptosis[1][2].

Trametinib DMSO solvate
MBS5752199-100mg 100mg
EUR 180

Trametinib DMSO solvate
MBS5752199-10mg 10mg
EUR 145

Trametinib DMSO solvate
MBS5752199-200mg 200mg
EUR 225

Trametinib DMSO solvate
MBS5752199-25mg 25mg
EUR 145

Trametinib DMSO solvate
MBS5752199-50mg 50mg
EUR 160

Trametinib (DMSO solvate)
MBS3845880-100mg 100mg
EUR 425

Trametinib (DMSO solvate)
MBS3845880-10mg 10mg
EUR 140

Trametinib (DMSO solvate)
MBS3845880-25mg 25mg
EUR 200

Trametinib (DMSO solvate)
MBS3845880-50mg 50mg
EUR 275

Trametinib (DMSO solvate)
MBS3845880-5x100mg 5x100mg
EUR 1910

Trametinib DMSO solvate
MBS3600640-100mg 100mg
EUR 245

Trametinib DMSO solvate
MBS3600640-10mg 10mg
EUR 200

Trametinib DMSO solvate
MBS3600640-200mg 200mg
EUR 290
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