Effect of anti-TP0136 antibodies on the progression of lesions in an infected rabbit model.

TP0136 anti-syphilis antibodies in development are poorly understood. This study aimed to determine the effect of anti-TP0136 antibodies on lesion development in infected rabbit models. rTP0136 intramuscular injection into rabbits in the immunized group (n = 4) induce high titers of anti TP0136-antibody, and rabbit then challenged with 105T. pallidum per site along their back. lesion development was observed, and the injection sites were biopsied for tp0574 mRNA and histological analysis every week until the wound is healed. Rabbits in the control group were injected with normal saline instead rTP0136. Decent T. pallidum in rabbits challenged assessed by a test rabbit infectivity.

Lesions in the immunized group took longer to heal than in the control group (42 d vs 28 d, P <0.001) and had a real level higher than the number of cellular infiltrates. MRNA levels of tp0574 the immunized group was significantly higher than in the control group (P <0.05). Decent T. pallidum detected in the lymph nodes of rabbits in both groups were immunized and control. Our study shows that a high titer antibody anti TP0136-promoted infiltration of inflammatory cells into the local lesions and tissue damage intensive, thereby delaying wound healing, and does not have a protective effect on the occurrence of syphilis in a rabbit model.

Mouse Mitochondrial DNA Copy Number Kit
MCN3 1 Kit
EUR 418.8

Drain Tap Assembly to suit baths with serial number: 75100
BAT7360 EACH
EUR 79.2

piggyBac qPCR copy number kit, 20 reactions  
PBC100A-1 20 reactions
EUR 275

Kinesis Septa TCS 11mm Bought as part number without /S
CHR1750 EACH
EUR 4.27

Kinesis Obsolete see part number M-653 Headless; 10-32; 1/16
CHR3683 PK10
EUR 50.16

Trametinib, DMSO Solvate [CAS# 1187431-43-1]
T-8188 10 mg
EUR 38

DMSO
40470004-1 500 mL
EUR 69.23

DMSO
40470004-2 1 L
EUR 107.61

DMSO
40470004-3 100 mL
EUR 34.04

DMSO
40470004-4 250 mL
EUR 41.19

DMSO
40470004-5 50 mL
EUR 22.74

DMSO, anhydrous
90082 10ML
EUR 87.6
Description: Minimum order quantity: 1 unit of 10ML

Dry DMSO, 2ML
X022-2ML 2ML
EUR 37

Dry DMSO, 4ML
X022-4ML 4ML
EUR 54

Dry DMSO, 5ML
X022-5ML 5ML
EUR 59

Dry DMSO, 14ML
X022-14ML 14ML
EUR 109

Dry DMSO, 20ML
X022-20ML 20ML
EUR 168

Tips, 10ml for Propette (6-digit serial numbers, 2017 and prior)
P4310 150/pack
EUR 98.88
Description: Tips 10ml for Propette (6-digit serial numbers

DiTO™-1 [equivalent to TOTO®-1] *5 mM DMSO Solution* *CAS 143413-84-7*
17575-02ml 0.2 ml
EUR 222
Description: DiTO™-1 is chemically equivalent to TOTO®-1 (TOTO® is the trademark of Invitrogen).

DiYO™-3 [equivalent to YOYO®-3] *5 mM DMSO Solution* *CAS 156312-20-8*
17581-02ml 0.2 ml
EUR 222
Description: DiYO™-3 is chemically equivalent to YOYO®-3 (YOYO® is the trademark of Invitrogen).

Tips, 10mL for Propette LE (9-digit serial numbers, 2018 and beyond)
P4311 100/pack
EUR 98.88
Description: Tips 10mL for Propette LE (9-digit serial numbers

OPTIONAL HEAD,3 INCH,FOR PROCESSING LARGER NUMBERS OF TUBES
480100 1/pk
EUR 68.4
Description: Lab Equipment; Shakers & Mixers

DiTO™-1 [equivalent to TOTO®-1] *5 mM DMSO Solution* *CAS 143413-84-7*
17575 0.2 ml
EUR 222

DiYO™-3 [equivalent to YOYO®-3] *5 mM DMSO Solution* *CAS 156312-20-8*
17581 0.2 ml
EUR 222

MicroCrystal Mount Assortment, 2 each of numbers 1 - 12, on 18mm rods
M4-L18SP-A1 20 MOUNTS
EUR 125
Description: MicroCrystal Mount Assortment, 2 each of numbers 1 - 12, on 18mm rods

Trametinib DMSO solvate
A3887-10 10 mg
EUR 129.6
Description: Trametinib (also known as GSK1120212 or JTP 74057), originally identified as a p15 inductive compound, is a novel and potent allosteric inhibitor of MEK kinase, which exhibits ATP non-competitive inhibition against MEK1 and MEK2 kinase.

Trametinib DMSO solvate
A3887-100 100 mg
EUR 224.4
Description: Trametinib (also known as GSK1120212 or JTP 74057), originally identified as a p15 inductive compound, is a novel and potent allosteric inhibitor of MEK kinase, which exhibits ATP non-competitive inhibition against MEK1 and MEK2 kinase.

Trametinib DMSO solvate
A3887-5.1 10 mM (in 1mL DMSO)
EUR 135.6
Description: Trametinib (also known as GSK1120212 or JTP 74057), originally identified as a p15 inductive compound, is a novel and potent allosteric inhibitor of MEK kinase, which exhibits ATP non-competitive inhibition against MEK1 and MEK2 kinase.

Trametinib DMSO solvate
A3887-50 50 mg
EUR 170.4
Description: Trametinib (also known as GSK1120212 or JTP 74057), originally identified as a p15 inductive compound, is a novel and potent allosteric inhibitor of MEK kinase, which exhibits ATP non-competitive inhibition against MEK1 and MEK2 kinase.

Dimethyl sulfoxide (DMSO)
D0231 500ml
EUR 88.55

Trametinib (DMSO solvate)
HY-10999A 100mg
EUR 256.8

Embedding Molds - Silicone, Flat, Numbered Cavities - Opaque
23258-1 1each
EUR 90

Amphotericin B(100% DMSO)
E28XB0086-1 1ml
EUR 88.89

EvaGreen, 2000X in DMSO
31019 50uL
EUR 294
Description: Minimum order quantity: 1 unit of 50uL

TWO-PRO™ 1 [equivalent to TO-PRO®-1] *5 mM DMSO Solution* *CAS 157199-59-2*
17571-02ml 0.2 ml
EUR 222
Description: TWO-PRO™-1 is chemically equivalent to TO-PRO®-1 (TO-PRO® is the trademark of Invitrogen).

TWO-PRO™ 3 [equivalent to TO-PRO®-3] *5 mM DMSO Solution* *CAS 157199-63-8*
17572-02ml 0.2 ml
EUR 222
Description: TWO-PRO™-3 is chemically equivalent to TO-PRO®-3 (TO-PRO® is the trademark of Invitrogen).

6-Rox, SE in DMSO:(100uL)
90098 100uL
EUR 368.4
Description: Minimum order quantity: 1 unit of 100uL

6-TAMRA, SE in DMSO:100uL
90097 100uL
EUR 368.4
Description: Minimum order quantity: 1 unit of 100uL

Amphotericin B(1% DMSO)
E28XB0086-10 10ml
EUR 101.59

Amphotericin B(1% DMSO)
E28XB0086-100 100ml
EUR 438.1

TWO-PRO™ 1 [equivalent to TO-PRO®-1] *5 mM DMSO Solution* *CAS 157199-59-2*
17571 0.2 ml
EUR 222

TWO-PRO™ 3 [equivalent to TO-PRO®-3] *5 mM DMSO Solution* *CAS 157199-63-8*
17572 0.2 ml
EUR 222

Statebourne Biosystem 80 ICS - Vapour Phase 100 25 Cell Cryoboxes numbered racks 79 300
CRY3316 EACH
EUR 22956.36

Round Grid Mats, 12/pack White silicone rubber mats, with numbered compartments.
M-CEM-71172 -
EUR 83
Description: Round Grid Mats, 12/pack White silicone rubber mats, with numbered compartments.

DMSO, Molecular Biology Grade
40470006-1 100 mL
EUR 88.18

DMSO, Molecular Biology Grade
40470006-2 250 mL
EUR 150.19

DMSO, Molecular Biology Grade
40470006-3 500 mL
EUR 279.26

RedDot 2, 200X in DMSO
40061 250uL
EUR 434.4
Description: Minimum order quantity: 1 unit of 250uL

RedDot 2, 200X in DMSO
40061-1 1mL
EUR 673.2
Description: Minimum order quantity: 1 unit of 1mL

RedDot 2, 200X in DMSO
40061-T 25uL
EUR 157.2
Description: Minimum order quantity: 1 unit of 25uL

250mL DMSO Dimethyl Sulfoxide
25-950-CQC EACH
EUR 114

NucSpot 470, 1000X in DMSO
40083-T 20uL
EUR 127.2
Description: Minimum order quantity: 1 unit of 20uL

LysoView 540, 1000X in DMSO
70061 50uL
EUR 246
Description: Minimum order quantity: 1 unit of 50uL

LysoView 540, 1000X in DMSO
70061-T 10uL
EUR 112.8
Description: Minimum order quantity: 1 unit of 10uL

LysoViewâ„¢ 405, 1000X in DMSO
70066 50uL
EUR 241.2
Description: Minimum order quantity: 1 unit of 50uL

LysoViewâ„¢ 488, 1000X in DMSO
70067 50uL
EUR 241.2
Description: Minimum order quantity: 1 unit of 50uL

MitoViewâ„¢ 720, 1000X in DMSO
70068 20X50UG
EUR 306
Description: Minimum order quantity: 1 unit of 20X50UG

Oxazole Gold, 10,000X in DMSO
40094 1UL
EUR 205
Description: N/A

DMSO, labeling grade, 1 mL
15050 1 mL
EUR 44.4

DMSO Resistant Peel Seal Roll
PCR0852 1ROLL
EUR 1563.6

DMSO Resistant Peel Seal Roll
PCR0854 1ROLL
EUR 1717.2

DMSO Resistant Peel Seal Roll
PCR0856 1ROLL
EUR 53.01

DMSO Resistant Peel Seal Roll
PCR0858 1ROLL
EUR 397.2

DMSO Resistant Peel Seal Roll
PCR0860 1ROLL
EUR 1756.8

DMSO Resistant Peel Seal Roll
PCR0862 1ROLL
EUR 1928.4

DMSO Resistant Peel Seal Roll
PCR0864 1ROLL
EUR 51.44

LAMP Greenâ„¢ *50X DMSO Solution*
17555-100ul 100 ul
EUR 301
Description: Isothermal amplification methods provide detection of nucleic acid target sequence in a streamlined, exponential manner.

Q4everâ„¢ Green *1250X DMSO Solution*
17608-100ul 100 ul
EUR 151
Description: A real-time polymerase chain reaction (real-time PCR), also known as quantitative polymerase chain reaction (qPCR), is a popular laboratory technique of molecular biology based on the polymerase chain reaction (PCR).

Q4everâ„¢ Green *1250X DMSO Solution*
17609-2ml 2 ml
EUR 2029
Description: A real-time polymerase chain reaction (real-time PCR), also known as quantitative polymerase chain reaction (qPCR), is a popular laboratory technique of molecular biology based on the polymerase chain reaction (PCR).

Oxazole Red, 1 mM in DMSO
40105 1ML
EUR 332
Description: N/A

Peelbl DMSO Resistant AdhFoil sh
PCR0542 PK100
EUR 331.2

Oxazole Blue, 1 mM in DMSO
40091 1ML
EUR 366
Description: N/A

LysoView™ 650, 1000X IN DMSO
70059 1UL
EUR 171
Description: N/A

LysoView™ 550, 1000X in DMSO
70083 1UL
EUR 162
Description: N/A

LysoView™ 594, 1000X in DMSO
70084 1UL
EUR 162
Description: N/A

LysoView™ 640, 1000X in DMSO
70085 1UL
EUR 162
Description: N/A

LysoView™ 680, 1000X in DMSO
70086 1UL
EUR 210
Description: N/A

EGTA AM *10 mM DMSO solution*
21006 1 mL
EUR 166

NucSpot Live 488, 1000X in DMSO
40081-T 10uL
EUR 139.2
Description: Minimum order quantity: 1 unit of 10uL

TMRE, 2 mM solution in DMSO
70005 0.5ML
EUR 178.8
Description: Minimum order quantity: 1 unit of 0.5ML

EGTA AM *10 mM DMSO solution*
21006-1mL 1 mL
EUR 166
Description: EGTA AM is cell-permeable version of EGTA (ethylene glycol tetraacetic acid), a cell-permeable calcium chelator.

Cyanine7 azide, 100 uL, 10 mM/DMSO
15030 100 µl
EUR 129.6

Cyanine7.5 azide, 100 uL, 10 mM/DMSO
16030 100 µl
EUR 129.6

Cyanine3.5 azide, 100 uL, 10 mM/DMSO
12030 100 µl
EUR 129.6

Cyanine5 azide, 100 uL, 10 mM/DMSO
13030 100 µl
EUR 129.6

Cyanine3 azide, 100 uL, 10 mM/DMSO
11030 10 mM/DMSO
EUR 129.6

Cyanine5.5 azide, 500 uL, 10 mM/DMSO
34030 500 µl
EUR 218.4

Cyanine7 azide, 500 uL, 10 mM/DMSO
35030 500 µl
EUR 218.4

Cyanine7.5 azide, 500 uL, 10 mM/DMSO
36030 500 µl
EUR 218.4

Cyanine5 azide, 500 uL, 10 mM/DMSO
33030 500 µl
EUR 218.4

Cyanine3.5 azide, 500 uL, 10 mM/DMSO
32030 500 µl
EUR 218.4

Thiazole orange *10 mM in DMSO*
17519 10 mL
EUR 86

CYTO-13 *5 mM DMSO solution*
17553 0.5 mL
EUR 222

NucSpot Far-Red, 1000X in DMSO
40085-T 50uL
EUR 157.2
Description: Minimum order quantity: 1 unit of 50uL

Thiazole Green, 10, 000X in DMSO
40086-0.5mL 0.5mL
EUR 225.6
Description: Minimum order quantity: 1 unit of 0.5mL

Thiazole Green, 10, 000X in DMSO
40086-1mL 1mL
EUR 344.4
Description: Minimum order quantity: 1 unit of 1mL

Thiazole orange *10 mM in DMSO*
17519-10mL 10 mL
EUR 86
Description: Thiazole orange is a fluorescent DNA-binding dye for reticulocyte analysis.

CYTO-13 *5 mM DMSO solution*
17553-05mL 0.5 mL
EUR 222
Description: CYTO-13 is a fluorogenic, DNA-selective and cell-permeant dye for analyzing DNA content in living cells.

250 ug/mL Nitromethane in DMSO
USP-S2722-DMSO 1ML
EUR 109.2

LAMP Green® *50X DMSO Solution*
17555 100 ul
EUR 301

DMSO Resistant Peel Seal 100 She
PCR0866 PK100
EUR 145.2

Calcein AM, 4mm in anhydrous DMSO
80011-1 100uL
EUR 271.2
Description: Minimum order quantity: 1 unit of 100uL

NucView 488 Caspase-3 Substrate, 1mM in DMSO
10402 100uL
EUR 475.2
Description: Minimum order quantity: 1 unit of 100uL

NucView 488 Caspase-3 Substrate, 1mM in DMSO
10402-T 10uL
EUR 144
Description: Minimum order quantity: 1 unit of 10uL

NucSpot® 555/570, 1000X in DMSO
41033 1UL
EUR 418
Description: N/A

NucSpot® 650/665, 1000X in DMSO
41034 1UL
EUR 418
Description: N/A

NucSpot® 680/700, 1000X in DMSO
41035 1UL
EUR 470
Description: N/A

NucSpot® 568/580, 1000X in DMSO
41036 1UL
EUR 418
Description: N/A

NucSpot® 594/615, 1000X in DMSO
41037 1UL
EUR 418
Description: N/A

NucSpot® 750/780, 1000X in DMSO
41038 1UL
EUR 470
Description: N/A

NucSpot® 500/515, 1000X in DMSO
41040 1UL
EUR 400
Description: N/A

Q4ever™ Green *1250X DMSO Solution*
17608 100 ul
EUR 151

Q4ever™ Green *1250X DMSO Solution*
17609 2 ml
EUR 2029

3600 ug/mL Tetrahyrdofuran in DMSO
USP-S3460-DMSO 1ML
EUR 109.2

DMSO Bio-Max, Cell Culture Grade
40470005-1 50 mL
EUR 94.72

DMSO Bio-Max, Cell Culture Grade
40470005-2 100 mL
EUR 158.19

DMSO Bio-Max, Cell Culture Grade
40470005-3 25 mL
EUR 53.53

DMSO Bio-Max, Cell Culture Grade
40470005-4 250 mL
EUR 271.78

Oxazole Yellow Homodimer, 1mM in DMSO
40090 1UL
EUR 299
Description: N/A

Cyanine5.5 azide, 1 mL, 10 mM/DMSO
44030 1 ml
EUR 379.2

Cyanine3.5 azide, 1 mL, 10 mM/DMSO
42030 1 ml
EUR 379.2

Cyanine5 azide, 1 mL, 10 mM/DMSO
43030 1 ml
EUR 379.2

Cyanine3 azide, 1 mL, 10 mM/DMSO
41030 10 mM/DMSO
EUR 379.2

NucView 405 Caspase-3 Substrate, 1 mM in DMSO
10405 100uL
EUR 475.2
Description: Minimum order quantity: 1 unit of 100uL

NucView 530 Caspase-3 Substrate, 1 mM in DMSO
10406 100uL
EUR 475.2
Description: Minimum order quantity: 1 unit of 100uL

MycoLightâ„¢ Red JJ94 *2.5 mM in DMSO*
24006-100uL 100 uL
EUR 334
Description: Green fluorescent protein (GFP) derivatives are widely used as fluorescent reporters to study biological processes at the cellular and molecular level, including labeling bacteria.

3100 ug/mL Ethylene Glycol in DMSO
USP-S1952-DMSO 1ML
EUR 109.2

Deacetylase Inhibitor Cocktail (100× in 70% DMSO)
K1017-1 1 ml
EUR 104.4

Deacetylase Inhibitor Cocktail (100× in 70% DMSO)
K1017-10 10x1 ml
EUR 282
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