TP0136 anti-syphilis antibodies in development are poorly understood. This study aimed to determine the effect of anti-TP0136 antibodies on lesion development in infected rabbit models. rTP0136 intramuscular injection into rabbits in the immunized group (n = 4) induce high titers of anti TP0136-antibody, and rabbit then challenged with 105T. pallidum per site along their back. lesion development was observed, and the injection sites were biopsied for tp0574 mRNA and histological analysis every week until the wound is healed. Rabbits in the control group were injected with normal saline instead rTP0136. Decent T. pallidum in rabbits challenged assessed by a test rabbit infectivity.
Lesions in the immunized group took longer to heal than in the control group (42 d vs 28 d, P <0.001) and had a real level higher than the number of cellular infiltrates. MRNA levels of tp0574 the immunized group was significantly higher than in the control group (P <0.05). Decent T. pallidum detected in the lymph nodes of rabbits in both groups were immunized and control. Our study shows that a high titer antibody anti TP0136-promoted infiltration of inflammatory cells into the local lesions and tissue damage intensive, thereby delaying wound healing, and does not have a protective effect on the occurrence of syphilis in a rabbit model.
DMSO, anhydrous |
90082 |
Biotium |
10ML |
EUR 73 |
Description: Minimum order quantity: 1 unit of 10ML |
piggyBac qPCR copy number kit, 20 reactions |
PBC100A-1 |
SBI |
20 reactions |
EUR 331 |
|
Dimethyl sulfoxide (DMSO) |
D0231 |
Bio Basic |
500ml |
EUR 73.79 |
|
Trametinib DMSO solvate |
A3887-10 |
ApexBio |
10 mg |
EUR 108 |
Description: Trametinib (also known as GSK1120212 or JTP 74057), originally identified as a p15 inductive compound, is a novel and potent allosteric inhibitor of MEK kinase, which exhibits ATP non-competitive inhibition against MEK1 and MEK2 kinase. |
Trametinib DMSO solvate |
A3887-100 |
ApexBio |
100 mg |
EUR 187 |
Description: Trametinib (also known as GSK1120212 or JTP 74057), originally identified as a p15 inductive compound, is a novel and potent allosteric inhibitor of MEK kinase, which exhibits ATP non-competitive inhibition against MEK1 and MEK2 kinase. |
Trametinib DMSO solvate |
A3887-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 113 |
Description: Trametinib (also known as GSK1120212 or JTP 74057), originally identified as a p15 inductive compound, is a novel and potent allosteric inhibitor of MEK kinase, which exhibits ATP non-competitive inhibition against MEK1 and MEK2 kinase. |
Trametinib DMSO solvate |
A3887-50 |
ApexBio |
50 mg |
EUR 142 |
Description: Trametinib (also known as GSK1120212 or JTP 74057), originally identified as a p15 inductive compound, is a novel and potent allosteric inhibitor of MEK kinase, which exhibits ATP non-competitive inhibition against MEK1 and MEK2 kinase. |
CAS Antibody |
AF9032 |
Affbiotech |
200ul |
EUR 304 |
Description: CAS Antibody detects endogenous levels of total CAS. |
CAS antibody |
70R-31499 |
Fitzgerald |
100 ug |
EUR 327 |
Description: Rabbit polyclonal CAS antibody |
DiTO™-1 [equivalent to TOTO®-1] *5 mM DMSO Solution* *CAS 143413-84-7* |
17575 |
AAT Bioquest |
0.2 ml |
EUR 219 |
|
EvaGreen, 2000X in DMSO |
31019 |
Biotium |
50uL |
EUR 245 |
Description: Minimum order quantity: 1 unit of 50uL |
DMAO, 2mM in DMSO |
40012 |
Biotium |
1ML |
EUR 296 |
Description: Minimum order quantity: 1 unit of 1ML |
CAS Polyclonal Antibody |
ES1844-100ul |
ELK Biotech |
100ul |
EUR 279 |
Description: A Rabbit Polyclonal antibody against CAS from Human. This antibody is tested and validated for WB, ELISA, IHC, IP, IF, WB, ELISA |
CAS Polyclonal Antibody |
ES1844-50ul |
ELK Biotech |
50ul |
EUR 207 |
Description: A Rabbit Polyclonal antibody against CAS from Human. This antibody is tested and validated for WB, ELISA, IHC, IP, IF, WB, ELISA |
Anti-CAS Antibody |
A04496 |
BosterBio |
100ul |
EUR 397 |
Description: Rabbit Polyclonal Antibody for CAS Antibody (CSE1L) detection.tested for IP, WB in Human. |
CAS Polyclonal Antibody |
ABP50845-003ml |
Abbkine |
0.03ml |
EUR 158 |
|
Description: A polyclonal antibody for detection of CAS from Human. This CAS antibody is for WB, IHC-P, IP, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the N-terminal region of human CAS at AA range: 1-80 |
CAS Polyclonal Antibody |
ABP50845-01ml |
Abbkine |
0.1ml |
EUR 289 |
|
Description: A polyclonal antibody for detection of CAS from Human. This CAS antibody is for WB, IHC-P, IP, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the N-terminal region of human CAS at AA range: 1-80 |
CAS Polyclonal Antibody |
ABP50845-02ml |
Abbkine |
0.2ml |
EUR 414 |
|
Description: A polyclonal antibody for detection of CAS from Human. This CAS antibody is for WB, IHC-P, IP, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the N-terminal region of human CAS at AA range: 1-80 |
p130 Cas Antibody |
20-abx012761 |
Abbexa |
-
EUR 314.00
-
EUR 98.00
-
EUR 398.00
-
EUR 495.00
|
-
100 ug
-
10 ug
-
200 ug
-
300 µg
|
|
Anti-CAS antibody |
STJ92006 |
St John's Laboratory |
200 µl |
EUR 197 |
Description: Rabbit polyclonal to CAS. |
CAS Polyclonal Antibody |
40671-100ul |
SAB |
100ul |
EUR 252 |
CAS Polyclonal Antibody |
40671-50ul |
SAB |
50ul |
EUR 187 |
p130 Cas Antibody |
AF6350 |
Affbiotech |
200ul |
EUR 304 |
Description: p130 Cas Antibody detects endogenous levels of total p130 Cas. |
p130 Cas Antibody |
AF7826 |
Affbiotech |
200ul |
EUR 376 |
Description: p130 Cas Antibody detects endogenous levels of p130 Cas. |
p130 Cas Antibody |
AF7827 |
Affbiotech |
200ul |
EUR 376 |
Description: p130 Cas Antibody detects endogenous levels of p130 Cas. |
CAS Blocking Peptide |
AF9032-BP |
Affbiotech |
1mg |
EUR 195 |
p130 Cas Antibody |
AF4748 |
Affbiotech |
200ul |
EUR 376 |
Description: p130 Cas Antibody detects endogenous levels of p130 Cas. |
p130 Cas antibody |
70R-31036 |
Fitzgerald |
100 ug |
EUR 327 |
Description: Rabbit polyclonal p130 Cas antibody |
CAS antibody (Tyr165) |
70R-31498 |
Fitzgerald |
100 ug |
EUR 327 |
Description: Rabbit polyclonal CAS antibody (Tyr165) |
CAS antibody (Tyr249) |
70R-31500 |
Fitzgerald |
100 ug |
EUR 327 |
Description: Rabbit polyclonal CAS antibody (Tyr249) |
DiYO™-3 [equivalent to YO-YO®-3] *5 mM DMSO Solution* *CAS 156312-20-8* |
17581 |
AAT Bioquest |
0.2 ml |
EUR 219 |
|
TWO-PRO™ 1 [equivalent to TO-PRO®-1] *5 mM DMSO Solution* *CAS 157199-59-2* |
17571 |
AAT Bioquest |
0.2 ml |
EUR 219 |
|
TWO-PRO™ 3 [equivalent to TO-PRO®-3] *5 mM DMSO Solution* *CAS 157199-63-8* |
17572 |
AAT Bioquest |
0.2 ml |
EUR 219 |
|
RedDot 2, 200X in DMSO |
40061 |
Biotium |
250uL |
EUR 362 |
Description: Minimum order quantity: 1 unit of 250uL |
RedDot 2, 200X in DMSO |
40061-1 |
Biotium |
1mL |
EUR 561 |
Description: Minimum order quantity: 1 unit of 1mL |
RedDot 2, 200X in DMSO |
40061-T |
Biotium |
25uL |
EUR 131 |
Description: Minimum order quantity: 1 unit of 25uL |
Thiazole Orange, 10mM in DMSO |
40077 |
Biotium |
1mL |
EUR 145 |
Description: Minimum order quantity: 1 unit of 1mL |
NucSpot 470, 1000X in DMSO |
40083 |
Biotium |
200uL |
EUR 372 |
Description: Minimum order quantity: 1 unit of 200uL |
NucSpot 470, 1000X in DMSO |
40083-T |
Biotium |
20uL |
EUR 106 |
Description: Minimum order quantity: 1 unit of 20uL |
Thiazole Red, 1mM in DMSO |
40087 |
Biotium |
1mL |
EUR 320 |
Description: Minimum order quantity: 1 unit of 1mL |
Oxazole Yellow, 1mM in DMSO |
40089 |
Biotium |
1mL |
EUR 336 |
Description: Minimum order quantity: 1 unit of 1mL |
LysoView 540, 1000X in DMSO |
70061 |
Biotium |
50uL |
EUR 205 |
Description: Minimum order quantity: 1 unit of 50uL |
LysoView 540, 1000X in DMSO |
70061-T |
Biotium |
10uL |
EUR 94 |
Description: Minimum order quantity: 1 unit of 10uL |
LysoViewâ„¢ 405, 1000X in DMSO |
70066 |
Biotium |
50uL |
EUR 201 |
Description: Minimum order quantity: 1 unit of 50uL |
LysoViewâ„¢ 488, 1000X in DMSO |
70067 |
Biotium |
50uL |
EUR 201 |
Description: Minimum order quantity: 1 unit of 50uL |
MitoViewâ„¢ 720, 1000X in DMSO |
70068 |
Biotium |
20X50UG |
EUR 255 |
Description: Minimum order quantity: 1 unit of 20X50UG |
250 ML DMSO (DIMETHYL SULFOXIDE) |
25-950-CQC |
CORNING |
250 mL/pk |
EUR 94 |
Description: Media Catalog; Cell Culture Reagents |
DMSO, labeling grade, 1 mL |
15050 |
Lumiprobe |
1 mL |
EUR 37 |
p130 Cas Polyclonal Antibody |
ES3093-100ul |
ELK Biotech |
100ul |
EUR 279 |
Description: A Rabbit Polyclonal antibody against p130 Cas from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
p130 Cas Polyclonal Antibody |
ES3093-50ul |
ELK Biotech |
50ul |
EUR 207 |
Description: A Rabbit Polyclonal antibody against p130 Cas from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
p130 Cas Polyclonal Antibody |
ES3094-100ul |
ELK Biotech |
100ul |
EUR 279 |
Description: A Rabbit Polyclonal antibody against p130 Cas from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
p130 Cas Polyclonal Antibody |
ES3094-50ul |
ELK Biotech |
50ul |
EUR 207 |
Description: A Rabbit Polyclonal antibody against p130 Cas from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
p130 Cas Polyclonal Antibody |
ABP52094-003ml |
Abbkine |
0.03ml |
EUR 158 |
|
Description: A polyclonal antibody for detection of p130 Cas from Human, Mouse, Rat. This p130 Cas antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p130 Cas around the non-phosphorylation site of Y165 |
p130 Cas Polyclonal Antibody |
ABP52094-01ml |
Abbkine |
0.1ml |
EUR 289 |
|
Description: A polyclonal antibody for detection of p130 Cas from Human, Mouse, Rat. This p130 Cas antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p130 Cas around the non-phosphorylation site of Y165 |
p130 Cas Polyclonal Antibody |
ABP52094-02ml |
Abbkine |
0.2ml |
EUR 414 |
|
Description: A polyclonal antibody for detection of p130 Cas from Human, Mouse, Rat. This p130 Cas antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p130 Cas around the non-phosphorylation site of Y165 |
p130 Cas Polyclonal Antibody |
ABP52095-003ml |
Abbkine |
0.03ml |
EUR 158 |
|
Description: A polyclonal antibody for detection of p130 Cas from Human, Mouse, Rat. This p130 Cas antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p130 Cas around the non-phosphorylation site of Y410 |
p130 Cas Polyclonal Antibody |
ABP52095-01ml |
Abbkine |
0.1ml |
EUR 289 |
|
Description: A polyclonal antibody for detection of p130 Cas from Human, Mouse, Rat. This p130 Cas antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p130 Cas around the non-phosphorylation site of Y410 |
p130 Cas Polyclonal Antibody |
ABP52095-02ml |
Abbkine |
0.2ml |
EUR 414 |
|
Description: A polyclonal antibody for detection of p130 Cas from Human, Mouse, Rat. This p130 Cas antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p130 Cas around the non-phosphorylation site of Y410 |
AE-1477 EzBlock CAS |
2332617 |
Atto |
3unit |
EUR 294 |
Description: Casei n for wer st er n bl ot t i ng |
p130 Cas (pT249) Antibody |
20-abx009713 |
Abbexa |
-
EUR 314.00
-
EUR 467.00
-
EUR 203.00
|
|
|
p130 Cas (pY410) Antibody |
abx010316-100ug |
Abbexa |
100 ug |
EUR 439 |
|
Anti-p130 Cas antibody |
STJ94853 |
St John's Laboratory |
200 µl |
EUR 197 |
Description: Rabbit polyclonal to p130 Cas. |
Anti-p130 Cas antibody |
STJ94854 |
St John's Laboratory |
200 µl |
EUR 197 |
Description: Rabbit polyclonal to p130 Cas. |
CAS Polyclonal Conjugated Antibody |
C40671 |
SAB |
100ul |
EUR 397 |
p130 Cas Blocking Peptide |
AF6350-BP |
Affbiotech |
1mg |
EUR 195 |
p130 Cas Blocking Peptide |
AF7826-BP |
Affbiotech |
1mg |
EUR 195 |
p130 Cas Blocking Peptide |
AF7827-BP |
Affbiotech |
1mg |
EUR 195 |
p130 Cas Blocking Peptide |
AF4748-BP |
Affbiotech |
1mg |
EUR 195 |
p130 Cas antibody (Tyr410) |
70R-31035 |
Fitzgerald |
100 ug |
EUR 327 |
Description: Rabbit polyclonal p130 Cas antibody (Tyr410) |
Donkey Anti-Sheep IgG, Salt Fractionation (Bulk) |
30326-CAS-BLK |
Alpha Diagnostics |
1g; bulk |
Ask for price |
Thiazole orange *10 mM in DMSO* |
17519 |
AAT Bioquest |
10 mL |
EUR 115 |
|
EGTA AM *10 mM DMSO solution* |
21006 |
AAT Bioquest |
1 mL |
EUR 176 |
|
Ethidium homodimer I, 2mM DMSO solution |
40014 |
Biotium |
0.5ML |
EUR 257 |
Description: Minimum order quantity: 1 unit of 0.5ML |
Ethidium homodimer III, 1mM in DMSO |
40051 |
Biotium |
200uL |
EUR 312 |
Description: Minimum order quantity: 1 unit of 200uL |
Thiazole Red Homodimer, 1mM in DMSO |
40080 |
Biotium |
200uL |
EUR 355 |
Description: Minimum order quantity: 1 unit of 200uL |
NucSpot Live 488, 1000X in DMSO |
40081 |
Biotium |
50uL |
EUR 355 |
Description: Minimum order quantity: 1 unit of 50uL |
NucSpot Live 488, 1000X in DMSO |
40081-T |
Biotium |
10uL |
EUR 116 |
Description: Minimum order quantity: 1 unit of 10uL |
NucSpot Far-Red, 1000X in DMSO |
40085 |
Biotium |
0.5mL |
EUR 563 |
Description: Minimum order quantity: 1 unit of 0.5mL |
NucSpot Far-Red, 1000X in DMSO |
40085-T |
Biotium |
50uL |
EUR 131 |
Description: Minimum order quantity: 1 unit of 50uL |
Thiazole Green, 10, 000X in DMSO |
40086-0.5mL |
Biotium |
0.5mL |
EUR 188 |
Description: Minimum order quantity: 1 unit of 0.5mL |
Thiazole Green, 10, 000X in DMSO |
40086-1mL |
Biotium |
1mL |
EUR 287 |
Description: Minimum order quantity: 1 unit of 1mL |
TMRE, 2 mM solution in DMSO |
70005 |
Biotium |
0.5ML |
EUR 149 |
Description: Minimum order quantity: 1 unit of 0.5ML |
Calcein AM, 4mm in anhydrous DMSO |
80011-1 |
Biotium |
100uL |
EUR 226 |
Description: Minimum order quantity: 1 unit of 100uL |
6-TAMRA, SE in DMSO:100uL |
90097 |
Biotium |
100uL |
EUR 307 |
Description: Minimum order quantity: 1 unit of 100uL |
6-Rox, SE in DMSO:(100uL) |
90098 |
Biotium |
100uL |
EUR 307 |
Description: Minimum order quantity: 1 unit of 100uL |
Cycloheximide Solution (10% in DMSO Sterile) |
C084-10x1ML |
TOKU-E |
10x1 mL |
EUR 194 |
Cycloheximide Solution (10% in DMSO Sterile) |
C084-1ML |
TOKU-E |
1 mL |
EUR 54 |