TP0136 anti-syphilis antibodies in development are poorly understood. This study aimed to determine the effect of anti-TP0136 antibodies on lesion development in infected rabbit models. rTP0136 intramuscular injection into rabbits in the immunized group (n = 4) induce high titers of anti TP0136-antibody, and rabbit then challenged with 105T. pallidum per site along their back. lesion development was observed, and the injection sites were biopsied for tp0574 mRNA and histological analysis every week until the wound is healed. Rabbits in the control group were injected with normal saline instead rTP0136. Decent T. pallidum in rabbits challenged assessed by a test rabbit infectivity.
Lesions in the immunized group took longer to heal than in the control group (42 d vs 28 d, P <0.001) and had a real level higher than the number of cellular infiltrates. MRNA levels of tp0574 the immunized group was significantly higher than in the control group (P <0.05). Decent T. pallidum detected in the lymph nodes of rabbits in both groups were immunized and control. Our study shows that a high titer antibody anti TP0136-promoted infiltration of inflammatory cells into the local lesions and tissue damage intensive, thereby delaying wound healing, and does not have a protective effect on the occurrence of syphilis in a rabbit model.
Mouse Mitochondrial DNA Copy Number Kit |
MCN3 |
Detroit R&D |
1 Kit |
EUR 418.8 |
piggyBac qPCR copy number kit, 20 reactions |
PBC100A-1 |
SBI |
20 reactions |
EUR 275 |
Trametinib, DMSO Solvate [CAS# 1187431-43-1] |
T-8188 |
LC LABORATORIES |
10 mg |
EUR 38 |
DMSO, anhydrous |
90082 |
Biotium |
10ML |
EUR 87.6 |
Description: Minimum order quantity: 1 unit of 10ML |
Tips, 10ml for Propette (6-digit serial numbers, 2017 and prior) |
P4310 |
MTC Bio |
150/pack |
EUR 98.88 |
Description: Tips 10ml for Propette (6-digit serial numbers |
DiTO™-1 [equivalent to TOTO®-1] *5 mM DMSO Solution* *CAS 143413-84-7* |
17575-02ml |
AAT Bioquest |
0.2 ml |
EUR 222 |
|
Description: DiTO™-1 is chemically equivalent to TOTO®-1 (TOTO® is the trademark of Invitrogen). |
DiYO™-3 [equivalent to YOYO®-3] *5 mM DMSO Solution* *CAS 156312-20-8* |
17581-02ml |
AAT Bioquest |
0.2 ml |
EUR 222 |
|
Description: DiYO™-3 is chemically equivalent to YOYO®-3 (YOYO® is the trademark of Invitrogen). |
Tips, 10mL for Propette LE (9-digit serial numbers, 2018 and beyond) |
P4311 |
MTC Bio |
100/pack |
EUR 98.88 |
Description: Tips 10mL for Propette LE (9-digit serial numbers |
OPTIONAL HEAD,3 INCH,FOR PROCESSING LARGER NUMBERS OF TUBES |
480100 |
CORNING |
1/pk |
EUR 68.4 |
Description: Lab Equipment; Shakers & Mixers |
DiTO™-1 [equivalent to TOTO®-1] *5 mM DMSO Solution* *CAS 143413-84-7* |
17575 |
AAT Bioquest |
0.2 ml |
EUR 222 |
DiYO™-3 [equivalent to YOYO®-3] *5 mM DMSO Solution* *CAS 156312-20-8* |
17581 |
AAT Bioquest |
0.2 ml |
EUR 222 |
MicroCrystal Mount Assortment, 2 each of numbers 1 - 12, on 18mm rods |
M4-L18SP-A1 |
MiTeGen |
20 MOUNTS |
EUR 125 |
Description: MicroCrystal Mount Assortment, 2 each of numbers 1 - 12, on 18mm rods |
Trametinib DMSO solvate |
A3887-10 |
ApexBio |
10 mg |
EUR 129.6 |
Description: Trametinib (also known as GSK1120212 or JTP 74057), originally identified as a p15 inductive compound, is a novel and potent allosteric inhibitor of MEK kinase, which exhibits ATP non-competitive inhibition against MEK1 and MEK2 kinase. |
Trametinib DMSO solvate |
A3887-100 |
ApexBio |
100 mg |
EUR 224.4 |
Description: Trametinib (also known as GSK1120212 or JTP 74057), originally identified as a p15 inductive compound, is a novel and potent allosteric inhibitor of MEK kinase, which exhibits ATP non-competitive inhibition against MEK1 and MEK2 kinase. |
Trametinib DMSO solvate |
A3887-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 135.6 |
Description: Trametinib (also known as GSK1120212 or JTP 74057), originally identified as a p15 inductive compound, is a novel and potent allosteric inhibitor of MEK kinase, which exhibits ATP non-competitive inhibition against MEK1 and MEK2 kinase. |
Trametinib DMSO solvate |
A3887-50 |
ApexBio |
50 mg |
EUR 170.4 |
Description: Trametinib (also known as GSK1120212 or JTP 74057), originally identified as a p15 inductive compound, is a novel and potent allosteric inhibitor of MEK kinase, which exhibits ATP non-competitive inhibition against MEK1 and MEK2 kinase. |
Dimethyl sulfoxide (DMSO) |
D0231 |
Bio Basic |
500ml |
EUR 88.55 |
|
Amphotericin B(100% DMSO) |
E28XB0086-1 |
EnoGene |
1ml |
EUR 88.89 |
EvaGreen, 2000X in DMSO |
31019 |
Biotium |
50uL |
EUR 294 |
Description: Minimum order quantity: 1 unit of 50uL |
TWO-PRO™ 1 [equivalent to TO-PRO®-1] *5 mM DMSO Solution* *CAS 157199-59-2* |
17571-02ml |
AAT Bioquest |
0.2 ml |
EUR 222 |
|
Description: TWO-PRO™-1 is chemically equivalent to TO-PRO®-1 (TO-PRO® is the trademark of Invitrogen). |
TWO-PRO™ 3 [equivalent to TO-PRO®-3] *5 mM DMSO Solution* *CAS 157199-63-8* |
17572-02ml |
AAT Bioquest |
0.2 ml |
EUR 222 |
|
Description: TWO-PRO™-3 is chemically equivalent to TO-PRO®-3 (TO-PRO® is the trademark of Invitrogen). |
6-Rox, SE in DMSO:(100uL) |
90098 |
Biotium |
100uL |
EUR 368.4 |
Description: Minimum order quantity: 1 unit of 100uL |
6-TAMRA, SE in DMSO:100uL |
90097 |
Biotium |
100uL |
EUR 368.4 |
Description: Minimum order quantity: 1 unit of 100uL |
Amphotericin B(1% DMSO) |
E28XB0086-10 |
EnoGene |
10ml |
EUR 101.59 |
Amphotericin B(1% DMSO) |
E28XB0086-100 |
EnoGene |
100ml |
EUR 438.1 |
TWO-PRO™ 1 [equivalent to TO-PRO®-1] *5 mM DMSO Solution* *CAS 157199-59-2* |
17571 |
AAT Bioquest |
0.2 ml |
EUR 222 |
TWO-PRO™ 3 [equivalent to TO-PRO®-3] *5 mM DMSO Solution* *CAS 157199-63-8* |
17572 |
AAT Bioquest |
0.2 ml |
EUR 222 |
Round Grid Mats, 12/pack
White silicone rubber mats, with numbered compartments. |
M-CEM-71172 |
MiTeGen |
- |
EUR 83 |
Description: Round Grid Mats, 12/pack White silicone rubber mats, with numbered compartments. |
DMSO, Molecular Biology Grade |
40470006-1 |
Bio-WORLD |
100 mL |
EUR 88.18 |
|
DMSO, Molecular Biology Grade |
40470006-2 |
Bio-WORLD |
250 mL |
EUR 150.19 |
|
DMSO, Molecular Biology Grade |
40470006-3 |
Bio-WORLD |
500 mL |
EUR 279.26 |
|
RedDot 2, 200X in DMSO |
40061 |
Biotium |
250uL |
EUR 434.4 |
Description: Minimum order quantity: 1 unit of 250uL |
RedDot 2, 200X in DMSO |
40061-1 |
Biotium |
1mL |
EUR 673.2 |
Description: Minimum order quantity: 1 unit of 1mL |
RedDot 2, 200X in DMSO |
40061-T |
Biotium |
25uL |
EUR 157.2 |
Description: Minimum order quantity: 1 unit of 25uL |
NucSpot 470, 1000X in DMSO |
40083-T |
Biotium |
20uL |
EUR 127.2 |
Description: Minimum order quantity: 1 unit of 20uL |
LysoView 540, 1000X in DMSO |
70061 |
Biotium |
50uL |
EUR 246 |
Description: Minimum order quantity: 1 unit of 50uL |
LysoView 540, 1000X in DMSO |
70061-T |
Biotium |
10uL |
EUR 112.8 |
Description: Minimum order quantity: 1 unit of 10uL |
LysoViewâ„¢ 405, 1000X in DMSO |
70066 |
Biotium |
50uL |
EUR 241.2 |
Description: Minimum order quantity: 1 unit of 50uL |
LysoViewâ„¢ 488, 1000X in DMSO |
70067 |
Biotium |
50uL |
EUR 241.2 |
Description: Minimum order quantity: 1 unit of 50uL |
MitoViewâ„¢ 720, 1000X in DMSO |
70068 |
Biotium |
20X50UG |
EUR 306 |
Description: Minimum order quantity: 1 unit of 20X50UG |
Oxazole Gold, 10,000X in DMSO |
40094 |
Biotium |
1UL |
EUR 205 |
|
Description: N/A |
DMSO, labeling grade, 1 mL |
15050 |
Lumiprobe |
1 mL |
EUR 44.4 |
LAMP Greenâ„¢ *50X DMSO Solution* |
17555-100ul |
AAT Bioquest |
100 ul |
EUR 301 |
|
Description: Isothermal amplification methods provide detection of nucleic acid target sequence in a streamlined, exponential manner. |
Q4everâ„¢ Green *1250X DMSO Solution* |
17608-100ul |
AAT Bioquest |
100 ul |
EUR 151 |
|
Description: A real-time polymerase chain reaction (real-time PCR), also known as quantitative polymerase chain reaction (qPCR), is a popular laboratory technique of molecular biology based on the polymerase chain reaction (PCR). |
Q4everâ„¢ Green *1250X DMSO Solution* |
17609-2ml |
AAT Bioquest |
2 ml |
EUR 2029 |
|
Description: A real-time polymerase chain reaction (real-time PCR), also known as quantitative polymerase chain reaction (qPCR), is a popular laboratory technique of molecular biology based on the polymerase chain reaction (PCR). |
Oxazole Red, 1 mM in DMSO |
40105 |
Biotium |
1ML |
EUR 332 |
|
Description: N/A |
Oxazole Blue, 1 mM in DMSO |
40091 |
Biotium |
1ML |
EUR 366 |
|
Description: N/A |
LysoView™ 650, 1000X IN DMSO |
70059 |
Biotium |
1UL |
EUR 171 |
|
Description: N/A |
LysoView™ 550, 1000X in DMSO |
70083 |
Biotium |
1UL |
EUR 162 |
|
Description: N/A |
LysoView™ 594, 1000X in DMSO |
70084 |
Biotium |
1UL |
EUR 162 |
|
Description: N/A |
LysoView™ 640, 1000X in DMSO |
70085 |
Biotium |
1UL |
EUR 162 |
|
Description: N/A |
LysoView™ 680, 1000X in DMSO |
70086 |
Biotium |
1UL |
EUR 210 |
|
Description: N/A |
EGTA AM *10 mM DMSO solution* |
21006 |
AAT Bioquest |
1 mL |
EUR 166 |
NucSpot Live 488, 1000X in DMSO |
40081-T |
Biotium |
10uL |
EUR 139.2 |
Description: Minimum order quantity: 1 unit of 10uL |
TMRE, 2 mM solution in DMSO |
70005 |
Biotium |
0.5ML |
EUR 178.8 |
Description: Minimum order quantity: 1 unit of 0.5ML |
EGTA AM *10 mM DMSO solution* |
21006-1mL |
AAT Bioquest |
1 mL |
EUR 166 |
|
Description: EGTA AM is cell-permeable version of EGTA (ethylene glycol tetraacetic acid), a cell-permeable calcium chelator. |
Cyanine7 azide, 100 uL, 10 mM/DMSO |
15030 |
Lumiprobe |
100 µl |
EUR 129.6 |
Cyanine7.5 azide, 100 uL, 10 mM/DMSO |
16030 |
Lumiprobe |
100 µl |
EUR 129.6 |
Cyanine3.5 azide, 100 uL, 10 mM/DMSO |
12030 |
Lumiprobe |
100 µl |
EUR 129.6 |
Cyanine5 azide, 100 uL, 10 mM/DMSO |
13030 |
Lumiprobe |
100 µl |
EUR 129.6 |
Cyanine3 azide, 100 uL, 10 mM/DMSO |
11030 |
Lumiprobe |
10 mM/DMSO |
EUR 129.6 |
Cyanine5.5 azide, 500 uL, 10 mM/DMSO |
34030 |
Lumiprobe |
500 µl |
EUR 218.4 |
Cyanine7 azide, 500 uL, 10 mM/DMSO |
35030 |
Lumiprobe |
500 µl |
EUR 218.4 |
Cyanine7.5 azide, 500 uL, 10 mM/DMSO |
36030 |
Lumiprobe |
500 µl |
EUR 218.4 |
Cyanine5 azide, 500 uL, 10 mM/DMSO |
33030 |
Lumiprobe |
500 µl |
EUR 218.4 |
Cyanine3.5 azide, 500 uL, 10 mM/DMSO |
32030 |
Lumiprobe |
500 µl |
EUR 218.4 |
Thiazole orange *10 mM in DMSO* |
17519 |
AAT Bioquest |
10 mL |
EUR 86 |
CYTO-13 *5 mM DMSO solution* |
17553 |
AAT Bioquest |
0.5 mL |
EUR 222 |
NucSpot Far-Red, 1000X in DMSO |
40085-T |
Biotium |
50uL |
EUR 157.2 |
Description: Minimum order quantity: 1 unit of 50uL |
Thiazole Green, 10, 000X in DMSO |
40086-0.5mL |
Biotium |
0.5mL |
EUR 225.6 |
Description: Minimum order quantity: 1 unit of 0.5mL |
Thiazole Green, 10, 000X in DMSO |
40086-1mL |
Biotium |
1mL |
EUR 344.4 |
Description: Minimum order quantity: 1 unit of 1mL |
Thiazole orange *10 mM in DMSO* |
17519-10mL |
AAT Bioquest |
10 mL |
EUR 86 |
|
Description: Thiazole orange is a fluorescent DNA-binding dye for reticulocyte analysis. |
CYTO-13 *5 mM DMSO solution* |
17553-05mL |
AAT Bioquest |
0.5 mL |
EUR 222 |
Description: CYTO-13 is a fluorogenic, DNA-selective and cell-permeant dye for analyzing DNA content in living cells. |
LAMP Green® *50X DMSO Solution* |
17555 |
AAT Bioquest |
100 ul |
EUR 301 |
Calcein AM, 4mm in anhydrous DMSO |
80011-1 |
Biotium |
100uL |
EUR 271.2 |
Description: Minimum order quantity: 1 unit of 100uL |
NucView 488 Caspase-3 Substrate, 1mM in DMSO |
10402 |
Biotium |
100uL |
EUR 475.2 |
Description: Minimum order quantity: 1 unit of 100uL |
NucView 488 Caspase-3 Substrate, 1mM in DMSO |
10402-T |
Biotium |
10uL |
EUR 144 |
Description: Minimum order quantity: 1 unit of 10uL |
NucSpot® 555/570, 1000X in DMSO |
41033 |
Biotium |
1UL |
EUR 418 |
|
Description: N/A |
NucSpot® 650/665, 1000X in DMSO |
41034 |
Biotium |
1UL |
EUR 418 |
|
Description: N/A |
NucSpot® 680/700, 1000X in DMSO |
41035 |
Biotium |
1UL |
EUR 470 |
|
Description: N/A |
NucSpot® 568/580, 1000X in DMSO |
41036 |
Biotium |
1UL |
EUR 418 |
|
Description: N/A |
NucSpot® 594/615, 1000X in DMSO |
41037 |
Biotium |
1UL |
EUR 418 |
|
Description: N/A |
NucSpot® 750/780, 1000X in DMSO |
41038 |
Biotium |
1UL |
EUR 470 |
|
Description: N/A |
NucSpot® 500/515, 1000X in DMSO |
41040 |
Biotium |
1UL |
EUR 400 |
|
Description: N/A |
Q4ever™ Green *1250X DMSO Solution* |
17608 |
AAT Bioquest |
100 ul |
EUR 151 |
Q4ever™ Green *1250X DMSO Solution* |
17609 |
AAT Bioquest |
2 ml |
EUR 2029 |
DMSO Bio-Max, Cell Culture Grade |
40470005-1 |
Bio-WORLD |
50 mL |
EUR 94.72 |
|
DMSO Bio-Max, Cell Culture Grade |
40470005-2 |
Bio-WORLD |
100 mL |
EUR 158.19 |
|
DMSO Bio-Max, Cell Culture Grade |
40470005-3 |
Bio-WORLD |
25 mL |
EUR 53.53 |
|
DMSO Bio-Max, Cell Culture Grade |
40470005-4 |
Bio-WORLD |
250 mL |
EUR 271.78 |
|
Oxazole Yellow Homodimer, 1mM in DMSO |
40090 |
Biotium |
1UL |
EUR 299 |
|
Description: N/A |
Cyanine5.5 azide, 1 mL, 10 mM/DMSO |
44030 |
Lumiprobe |
1 ml |
EUR 379.2 |
Cyanine3.5 azide, 1 mL, 10 mM/DMSO |
42030 |
Lumiprobe |
1 ml |
EUR 379.2 |
Cyanine5 azide, 1 mL, 10 mM/DMSO |
43030 |
Lumiprobe |
1 ml |
EUR 379.2 |
Cyanine3 azide, 1 mL, 10 mM/DMSO |
41030 |
Lumiprobe |
10 mM/DMSO |
EUR 379.2 |
NucView 405 Caspase-3 Substrate, 1 mM in DMSO |
10405 |
Biotium |
100uL |
EUR 475.2 |
Description: Minimum order quantity: 1 unit of 100uL |
NucView 530 Caspase-3 Substrate, 1 mM in DMSO |
10406 |
Biotium |
100uL |
EUR 475.2 |
Description: Minimum order quantity: 1 unit of 100uL |
MycoLightâ„¢ Red JJ94 *2.5 mM in DMSO* |
24006-100uL |
AAT Bioquest |
100 uL |
EUR 334 |
|
Description: Green fluorescent protein (GFP) derivatives are widely used as fluorescent reporters to study biological processes at the cellular and molecular level, including labeling bacteria. |
Deacetylase Inhibitor Cocktail (100× in 70% DMSO) |
K1017-1 |
ApexBio |
1 ml |
EUR 104.4 |
Deacetylase Inhibitor Cocktail (100× in 70% DMSO) |
K1017-10 |
ApexBio |
10x1 ml |
EUR 282 |