Effect of anti-TP0136 antibodies on the progression of lesions in an infected rabbit model.

TP0136 anti-syphilis antibodies in development are poorly understood. This study aimed to determine the effect of anti-TP0136 antibodies on lesion development in infected rabbit models. rTP0136 intramuscular injection into rabbits in the immunized group (n = 4) induce high titers of anti TP0136-antibody, and rabbit then challenged with 105T. pallidum per site along their back. lesion development was observed, and the injection sites were biopsied for tp0574 mRNA and histological analysis every week until the wound is healed. Rabbits in the control group were injected with normal saline instead rTP0136. Decent T. pallidum in rabbits challenged assessed by a test rabbit infectivity.

Lesions in the immunized group took longer to heal than in the control group (42 d vs 28 d, P <0.001) and had a real level higher than the number of cellular infiltrates. MRNA levels of tp0574 the immunized group was significantly higher than in the control group (P <0.05). Decent T. pallidum detected in the lymph nodes of rabbits in both groups were immunized and control. Our study shows that a high titer antibody anti TP0136-promoted infiltration of inflammatory cells into the local lesions and tissue damage intensive, thereby delaying wound healing, and does not have a protective effect on the occurrence of syphilis in a rabbit model.

DMSO, anhydrous

90082 10ML
EUR 73
Description: Minimum order quantity: 1 unit of 10ML

piggyBac qPCR copy number kit, 20 reactions  

PBC100A-1 20 reactions
EUR 331

Dry DMSO, 14ML

X022-14ML 14ML
EUR 143

Dry DMSO, 20ML

X022-20ML 20ML
EUR 194

Dry DMSO, 2ML

X022-2ML 2ML
EUR 94

Dry DMSO, 4ML

X022-4ML 4ML
EUR 116

Dry DMSO, 5ML

X022-5ML 5ML
EUR 122

Trametinib (DMSO solvate)

HY-10999A 100mg
EUR 214

Dimethyl sulfoxide (DMSO)

D0231 500ml
EUR 73.79

Trametinib DMSO solvate

A3887-10 10 mg
EUR 108
Description: Trametinib (also known as GSK1120212 or JTP 74057), originally identified as a p15 inductive compound, is a novel and potent allosteric inhibitor of MEK kinase, which exhibits ATP non-competitive inhibition against MEK1 and MEK2 kinase.

Trametinib DMSO solvate

A3887-100 100 mg
EUR 187
Description: Trametinib (also known as GSK1120212 or JTP 74057), originally identified as a p15 inductive compound, is a novel and potent allosteric inhibitor of MEK kinase, which exhibits ATP non-competitive inhibition against MEK1 and MEK2 kinase.

Trametinib DMSO solvate

A3887-5.1 10 mM (in 1mL DMSO)
EUR 113
Description: Trametinib (also known as GSK1120212 or JTP 74057), originally identified as a p15 inductive compound, is a novel and potent allosteric inhibitor of MEK kinase, which exhibits ATP non-competitive inhibition against MEK1 and MEK2 kinase.

Trametinib DMSO solvate

A3887-50 50 mg
EUR 142
Description: Trametinib (also known as GSK1120212 or JTP 74057), originally identified as a p15 inductive compound, is a novel and potent allosteric inhibitor of MEK kinase, which exhibits ATP non-competitive inhibition against MEK1 and MEK2 kinase.

CAS Antibody

AF9032 200ul
EUR 304
Description: CAS Antibody detects endogenous levels of total CAS.

CAS Antibody

ABF9032 100 ug
EUR 438

CAS antibody

70R-31499 100 ug
EUR 327
Description: Rabbit polyclonal CAS antibody

ELISA Kit Target

Catalog-Number Kit Size
EUR 50

DiTO™-1 [equivalent to TOTO®-1] *5 mM DMSO Solution* *CAS 143413-84-7*

17575 0.2 ml
EUR 219

EvaGreen, 2000X in DMSO

31019 50uL
EUR 245
Description: Minimum order quantity: 1 unit of 50uL

DMAO, 2mM in DMSO

40012 1ML
EUR 296
Description: Minimum order quantity: 1 unit of 1ML

CAS Polyclonal Antibody

ES1844-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against CAS from Human. This antibody is tested and validated for WB, ELISA, IHC, IP, IF, WB, ELISA

CAS Polyclonal Antibody

ES1844-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against CAS from Human. This antibody is tested and validated for WB, ELISA, IHC, IP, IF, WB, ELISA

Anti-CAS Antibody

A04496 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for CAS Antibody (CSE1L) detection.tested for IP, WB in Human.

CAS Polyclonal Antibody

ABP50845-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of CAS from Human. This CAS antibody is for WB, IHC-P, IP, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the N-terminal region of human CAS at AA range: 1-80

CAS Polyclonal Antibody

ABP50845-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of CAS from Human. This CAS antibody is for WB, IHC-P, IP, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the N-terminal region of human CAS at AA range: 1-80

CAS Polyclonal Antibody

ABP50845-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of CAS from Human. This CAS antibody is for WB, IHC-P, IP, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the N-terminal region of human CAS at AA range: 1-80

p130 Cas Antibody

20-abx012761
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Anti-CAS antibody

STJ92006 200 µl
EUR 197
Description: Rabbit polyclonal to CAS.

CAS Polyclonal Antibody

40671-100ul 100ul
EUR 252

CAS Polyclonal Antibody

40671-50ul 50ul
EUR 187

p130 Cas Antibody

AF6350 200ul
EUR 304
Description: p130 Cas Antibody detects endogenous levels of total p130 Cas.

p130 Cas Antibody

AF7826 200ul
EUR 376
Description: p130 Cas Antibody detects endogenous levels of p130 Cas.

p130 Cas Antibody

AF7827 200ul
EUR 376
Description: p130 Cas Antibody detects endogenous levels of p130 Cas.

CAS Blocking Peptide

AF9032-BP 1mg
EUR 195

p130 Cas Antibody

ABF6350 100 ug
EUR 438

p130 Cas Antibody

AF4748 200ul
EUR 376
Description: p130 Cas Antibody detects endogenous levels of p130 Cas.

p130 Cas antibody

70R-31036 100 ug
EUR 327
Description: Rabbit polyclonal p130 Cas antibody

CAS antibody (Tyr165)

70R-31498 100 ug
EUR 327
Description: Rabbit polyclonal CAS antibody (Tyr165)

CAS antibody (Tyr249)

70R-31500 100 ug
EUR 327
Description: Rabbit polyclonal CAS antibody (Tyr249)

DiYO™-3 [equivalent to YO-YO®-3] *5 mM DMSO Solution* *CAS 156312-20-8*

17581 0.2 ml
EUR 219

TWO-PRO™ 1 [equivalent to TO-PRO®-1] *5 mM DMSO Solution* *CAS 157199-59-2*

17571 0.2 ml
EUR 219

TWO-PRO™ 3 [equivalent to TO-PRO®-3] *5 mM DMSO Solution* *CAS 157199-63-8*

17572 0.2 ml
EUR 219

RedDot 2, 200X in DMSO

40061 250uL
EUR 362
Description: Minimum order quantity: 1 unit of 250uL

RedDot 2, 200X in DMSO

40061-1 1mL
EUR 561
Description: Minimum order quantity: 1 unit of 1mL

RedDot 2, 200X in DMSO

40061-T 25uL
EUR 131
Description: Minimum order quantity: 1 unit of 25uL

Thiazole Orange, 10mM in DMSO

40077 1mL
EUR 145
Description: Minimum order quantity: 1 unit of 1mL

NucSpot 470, 1000X in DMSO

40083 200uL
EUR 372
Description: Minimum order quantity: 1 unit of 200uL

NucSpot 470, 1000X in DMSO

40083-T 20uL
EUR 106
Description: Minimum order quantity: 1 unit of 20uL

Thiazole Red, 1mM in DMSO

40087 1mL
EUR 320
Description: Minimum order quantity: 1 unit of 1mL

Oxazole Yellow, 1mM in DMSO

40089 1mL
EUR 336
Description: Minimum order quantity: 1 unit of 1mL

LysoView 540, 1000X in DMSO

70061 50uL
EUR 205
Description: Minimum order quantity: 1 unit of 50uL

LysoView 540, 1000X in DMSO

70061-T 10uL
EUR 94
Description: Minimum order quantity: 1 unit of 10uL

LysoViewâ„¢ 405, 1000X in DMSO

70066 50uL
EUR 201
Description: Minimum order quantity: 1 unit of 50uL

LysoViewâ„¢ 488, 1000X in DMSO

70067 50uL
EUR 201
Description: Minimum order quantity: 1 unit of 50uL

MitoViewâ„¢ 720, 1000X in DMSO

70068 20X50UG
EUR 255
Description: Minimum order quantity: 1 unit of 20X50UG

250 ML DMSO (DIMETHYL SULFOXIDE)

25-950-CQC 250 mL/pk
EUR 94
Description: Media Catalog; Cell Culture Reagents

DMSO, labeling grade, 1 mL

15050 1 mL
EUR 37

p130 Cas Polyclonal Antibody

ES3093-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against p130 Cas from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

p130 Cas Polyclonal Antibody

ES3093-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against p130 Cas from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

p130 Cas Polyclonal Antibody

ES3094-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against p130 Cas from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

p130 Cas Polyclonal Antibody

ES3094-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against p130 Cas from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

p130 Cas Polyclonal Antibody

ABP52094-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of p130 Cas from Human, Mouse, Rat. This p130 Cas antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p130 Cas around the non-phosphorylation site of Y165

p130 Cas Polyclonal Antibody

ABP52094-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of p130 Cas from Human, Mouse, Rat. This p130 Cas antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p130 Cas around the non-phosphorylation site of Y165

p130 Cas Polyclonal Antibody

ABP52094-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of p130 Cas from Human, Mouse, Rat. This p130 Cas antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p130 Cas around the non-phosphorylation site of Y165

p130 Cas Polyclonal Antibody

ABP52095-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of p130 Cas from Human, Mouse, Rat. This p130 Cas antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p130 Cas around the non-phosphorylation site of Y410

p130 Cas Polyclonal Antibody

ABP52095-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of p130 Cas from Human, Mouse, Rat. This p130 Cas antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p130 Cas around the non-phosphorylation site of Y410

p130 Cas Polyclonal Antibody

ABP52095-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of p130 Cas from Human, Mouse, Rat. This p130 Cas antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p130 Cas around the non-phosphorylation site of Y410

AE-1477 EzBlock CAS

2332617 3unit
EUR 294
Description: Casei n for wer st er n bl ot t i ng

p130 Cas (pT249) Antibody

20-abx009713
  • EUR 314.00
  • EUR 467.00
  • EUR 203.00
  • 100 ul
  • 200 ul
  • 30 ul

p130 Cas (pY410) Antibody

abx010316-100ug 100 ug
EUR 439

Anti-p130 Cas antibody

STJ94853 200 µl
EUR 197
Description: Rabbit polyclonal to p130 Cas.

Anti-p130 Cas antibody

STJ94854 200 µl
EUR 197
Description: Rabbit polyclonal to p130 Cas.

CAS Polyclonal Conjugated Antibody

C40671 100ul
EUR 397

p130 Cas Blocking Peptide

AF6350-BP 1mg
EUR 195

p130 Cas Blocking Peptide

AF7826-BP 1mg
EUR 195

p130 Cas Blocking Peptide

AF7827-BP 1mg
EUR 195

p130 Cas Blocking Peptide

AF4748-BP 1mg
EUR 195

p130 Cas antibody (Tyr410)

70R-31035 100 ug
EUR 327
Description: Rabbit polyclonal p130 Cas antibody (Tyr410)

Donkey Anti-Sheep IgG, Salt Fractionation (Bulk)

30326-CAS-BLK 1g; bulk Ask for price

Thiazole orange *10 mM in DMSO*

17519 10 mL
EUR 115

EGTA AM *10 mM DMSO solution*

21006 1 mL
EUR 176

Ethidium homodimer I, 2mM DMSO solution

40014 0.5ML
EUR 257
Description: Minimum order quantity: 1 unit of 0.5ML

Ethidium homodimer III, 1mM in DMSO

40051 200uL
EUR 312
Description: Minimum order quantity: 1 unit of 200uL

Thiazole Red Homodimer, 1mM in DMSO

40080 200uL
EUR 355
Description: Minimum order quantity: 1 unit of 200uL

NucSpot Live 488, 1000X in DMSO

40081 50uL
EUR 355
Description: Minimum order quantity: 1 unit of 50uL

NucSpot Live 488, 1000X in DMSO

40081-T 10uL
EUR 116
Description: Minimum order quantity: 1 unit of 10uL

NucSpot Far-Red, 1000X in DMSO

40085 0.5mL
EUR 563
Description: Minimum order quantity: 1 unit of 0.5mL

NucSpot Far-Red, 1000X in DMSO

40085-T 50uL
EUR 131
Description: Minimum order quantity: 1 unit of 50uL

Thiazole Green, 10, 000X in DMSO

40086-0.5mL 0.5mL
EUR 188
Description: Minimum order quantity: 1 unit of 0.5mL

Thiazole Green, 10, 000X in DMSO

40086-1mL 1mL
EUR 287
Description: Minimum order quantity: 1 unit of 1mL

TMRE, 2 mM solution in DMSO

70005 0.5ML
EUR 149
Description: Minimum order quantity: 1 unit of 0.5ML

Calcein AM, 4mm in anhydrous DMSO

80011-1 100uL
EUR 226
Description: Minimum order quantity: 1 unit of 100uL

6-TAMRA, SE in DMSO:100uL

90097 100uL
EUR 307
Description: Minimum order quantity: 1 unit of 100uL

6-Rox, SE in DMSO:(100uL)

90098 100uL
EUR 307
Description: Minimum order quantity: 1 unit of 100uL

Cycloheximide Solution (10% in DMSO Sterile)

C084-10x1ML 10x1 mL
EUR 194

Cycloheximide Solution (10% in DMSO Sterile)

C084-1ML 1 mL
EUR 54
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