A monoclonal anti-interleukin 8 antibody (WS-4) inhibits cytokine response and acute lung injury in experimental severe acute necrotising pancreatitis in rabbits.
BACKGROUNDInterleukin 8 (IL-8) has lately been proposed to have an necessary function in mediating the event of the systemic sequelae related to severe acute pancreatitis.OBJECTIVETo outline the function of IL-8 in acute pancreatitis by neutralising its results with a monoclonal anti-IL-8 antibody (WS-4), in a rabbit mannequin of severe acute pancreatitis. METHODSAcute pancreatitis was induced …